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| I | Pumas UNAM | - | Atlas Guadalajara | 3:2 (2:2) | ||
| V | Atlas Guadalajara | - | Pumas UNAM | 4:0 (0:0) | ||
| I: 11.05.2022 17:00 | V: 14.05.2022 16:00 | Campeones: Atlas Guadalajara | ||||
| I | Club Tijuana | - | Santos Laguna | 1:1 (0:0) | ||
| V | Santos Laguna | - | Club Tijuana | 4:1 (1:1) | ||
| I: 12.05.2022 21:45 | V: 15.05.2022 17:00 | Campeones: Santos Laguna | ||||
