 |
 |
|
|
| 22.04.2022 | 18:15 | Puebla FC | - | Club Necaxa | 1:4 (0:3) | |
| 19:30 | FC Juárez | - | Mazatlán FC | 2:2 (1:0) | ||
| 23.04.2022 | 16:00 | CF Pachuca | - | CF Monterrey | 2:1 (0:0) | |
| 18:00 | UANL Tigres | - | CF América | 0:2 (0:1) | ||
| 18:15 | Deportivo Guadalajara | - | Pumas UNAM | 1:2 (1:0) | ||
| 24.04.2022 | 16:00 | Santos Laguna | - | Club León | 2:3 (1:1) | |
| 18:15 | Cruz Azul | - | Atlético San Luis | 2:1 (0:1) | ||
| 18:30 | Deportivo Toluca | - | Atlas Guadalajara | 1:0 (0:0) | ||
| 21:45 | Club Tijuana | - | Gallos Blancos | 4:1 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 16 | 11 | 3 | 2 | 36:16 | 20 | 46 |
| 2 |
|
Atlas Guadalajara | 16 | 9 | 5 | 2 | 26:13 | 13 | 43 |
| 3 |
|
Club León | 16 | 10 | 3 | 3 | 28:23 | 5 | 40 |
| 4 |
|
Club Tijuana | 16 | 8 | 4 | 4 | 30:25 | 5 | 39 |
| 5 |
|
Santos Laguna | 16 | 8 | 5 | 3 | 33:18 | 15 | 38 |
| 6 |
|
Deportivo Guadalajara | 16 | 7 | 5 | 4 | 31:20 | 11 | 34 |
| 7 |
|
Pumas UNAM | 16 | 8 | 3 | 5 | 25:20 | 5 | 34 |
| 8 |
|
Cruz Azul | 16 | 7 | 3 | 6 | 19:19 | 0 | 33 |
| 9 |
|
Deportivo Toluca | 16 | 6 | 6 | 4 | 25:18 | 7 | 32 |
| 10 |
|
CF Pachuca | 16 | 8 | 0 | 8 | 27:24 | 3 | 31 |
| 11 |
|
Atlético San Luis | 16 | 7 | 2 | 7 | 24:23 | 1 | 29 |
| 12 |
|
CF Monterrey | 16 | 5 | 2 | 9 | 26:35 | -9 | 28 |
| 13 |
|
Club Necaxa | 16 | 6 | 2 | 8 | 25:25 | 0 | 27 |
| 14 |
|
UANL Tigres | 16 | 4 | 4 | 8 | 17:31 | -14 | 25 |
| 15 |
|
Mazatlán FC | 16 | 2 | 5 | 9 | 17:34 | -17 | 21 |
| 16 |
|
FC Juárez | 16 | 2 | 5 | 9 | 18:30 | -12 | 18 |
| 17 |
|
Gallos Blancos | 16 | 3 | 2 | 11 | 11:26 | -15 | 18 |
| 18 |
|
Puebla FC | 16 | 1 | 5 | 10 | 14:32 | -18 | 17 |
| Playoff |
