 |
 |
|
| 29.04.2022 | 18:15 | Club Necaxa | - | Deportivo Guadalajara | 1:3 (0:1) | |
| 19:30 | Mazatlán FC | - | Puebla FC | 3:2 (2:1) | ||
| 30.04.2022 | 18:00 | CF América | - | Cruz Azul | 3:2 (0:1) | |
| 18:30 | Gallos Blancos | - | FC Juárez | 4:1 (1:1) | ||
| 18:30 | Atlas Guadalajara | - | UANL Tigres | 3:0 (1:0) | ||
| 18:30 | CF Monterrey | - | Club Tijuana | 1:1 (1:1) | ||
| 01.05.2022 | 18:30 | Pumas UNAM | - | CF Pachuca | 0:1 (0:0) | |
| 18:30 | Atlético San Luis | - | Santos Laguna | 0:1 (0:0) | ||
| 18:30 | Club León | - | Deportivo Toluca | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 17 | 12 | 3 | 2 | 39:18 | 21 | 49 |
| 2 |
|
Atlas Guadalajara | 17 | 10 | 5 | 2 | 29:13 | 16 | 46 |
| 3 |
|
Santos Laguna | 17 | 9 | 5 | 3 | 34:18 | 16 | 41 |
| 4 |
|
Club León | 17 | 10 | 4 | 3 | 28:23 | 5 | 41 |
| 5 |
|
Club Tijuana | 17 | 8 | 5 | 4 | 31:26 | 5 | 40 |
| 6 |
|
Deportivo Guadalajara | 17 | 8 | 5 | 4 | 34:21 | 13 | 37 |
| 7 |
|
CF Pachuca | 17 | 9 | 0 | 8 | 28:24 | 4 | 34 |
| 8 |
|
Pumas UNAM | 17 | 8 | 3 | 6 | 25:21 | 4 | 34 |
| 9 |
|
Deportivo Toluca | 17 | 6 | 7 | 4 | 25:18 | 7 | 33 |
| 10 |
|
Cruz Azul | 17 | 7 | 3 | 7 | 21:22 | -1 | 33 |
| 11 |
|
Atlético San Luis | 17 | 7 | 2 | 8 | 24:24 | 0 | 29 |
| 12 |
|
CF Monterrey | 17 | 5 | 3 | 9 | 27:36 | -9 | 29 |
| 13 |
|
Club Necaxa | 17 | 6 | 2 | 9 | 26:28 | -2 | 27 |
| 14 |
|
UANL Tigres | 17 | 4 | 4 | 9 | 17:34 | -17 | 25 |
| 15 |
|
Mazatlán FC | 17 | 3 | 5 | 9 | 20:36 | -16 | 24 |
| 16 |
|
Gallos Blancos | 17 | 4 | 2 | 11 | 15:27 | -12 | 21 |
| 17 |
|
FC Juárez | 17 | 2 | 5 | 10 | 19:34 | -15 | 18 |
| 18 |
|
Puebla FC | 17 | 1 | 5 | 11 | 16:35 | -19 | 17 |
| Playoff |
