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| I | Monarcas Morelia | - | Club León | 3:2 (1:0) | ||
| V | Club León | - | Monarcas Morelia | 2:0 (2:0) | ||
| I: 28.11.2018 17:00 | V: 01.12.2018 17:00 | Campeones: Club León | ||||
| I | Club Tijuana | - | Deportivo Guadalajara | 1:1 (0:0) | ||
| V | Deportivo Guadalajara | - | Club Tijuana | 3:1 (1:1) | ||
| I: 29.11.2018 05:00 | V: 01.12.2018 19:00 | Campeones: Deportivo Guadalajara | ||||
| I | Atlas Guadalajara | - | CF América | 2:1 (1:1) | ||
| V | CF América | - | Atlas Guadalajara | 3:2 (1:1) | ||
| I: 29.11.2018 16:00 | V: 02.12.2018 18:00 | Campeones: Atlas Guadalajara | ||||
| I | CF Monterrey | - | Deportivo Toluca | 1:1 (0:0) | ||
| V | Deportivo Toluca | - | CF Monterrey | 0:2 (0:1) | ||
| I: 29.11.2018 19:00 | V: 02.12.2018 16:00 | Campeones: CF Monterrey | ||||
