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| I | Monarcas Morelia | - | CF Monterrey | 1:2 (0:1) | ||
| V | CF Monterrey | - | Monarcas Morelia | 2:0 (0:0) | ||
| I: 08.05.2019 17:00 | V: 11.05.2019 16:00 | Campeones: CF Monterrey | ||||
| I | CF América | - | Atlas Guadalajara | 1:2 (0:1) | ||
| V | Atlas Guadalajara | - | CF América | 1:0 (1:0) | ||
| I: 08.05.2019 18:00 | V: 11.05.2019 17:00 | Campeones: Atlas Guadalajara | ||||
| I | UANL Tigres | - | CF Pachuca | 2:1 (0:0) | ||
| V | CF Pachuca | - | UANL Tigres | 2:2 (0:0) | ||
| I: 08.05.2019 18:00 | V: 12.05.2019 00:00 | Campeones: UANL Tigres | ||||
| I | Deportivo Toluca | - | Santos Laguna | 2:1 (1:0) | ||
| V | Santos Laguna | - | Deportivo Toluca | 2:0 (1:0) | ||
| I: 09.05.2019 16:00 | V: 12.05.2019 18:15 | Campeones: Santos Laguna | ||||
