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| I | Atlas Guadalajara | - | Deportivo Toluca | 3:0 (2:0) | ||
| V | Deportivo Toluca | - | Atlas Guadalajara | 0:0 (0:0) | ||
| I: 17.11.2021 16:00 | V: 20.11.2021 16:00 | Campeones: Atlas Guadalajara | ||||
| I | UANL Tigres | - | CF América | 4:2 (3:1) | ||
| V | CF América | - | UANL Tigres | 0:0 (0:0) | ||
| I: 17.11.2021 16:00 | V: 20.11.2021 19:30 | Campeones: UANL Tigres | ||||
| I | Mazatlán FC | - | Cruz Azul | 2:1 (1:0) | ||
| V | Cruz Azul | - | Mazatlán FC | 4:1 (2:0) | ||
| I: 17.11.2021 18:30 | V: 20.11.2021 16:00 | Campeones: Cruz Azul | ||||
| I | Club León | - | Santos Laguna | 1:0 (0:0) | ||
| V | Santos Laguna | - | Club León | 1:0 (0:0) | ||
| I: 18.11.2021 16:00 | V: 21.11.2021 18:00 | |||||
