 |
 |
|
|
| 10.09.2021 | 16:00 | Puebla FC | - | Atlético San Luis | 2:2 (0:1) | |
| 17:00 | FC Juárez | - | Cruz Azul | 0:1 (0:1) | ||
| 11.09.2021 | 00:45 | Club Tijuana | - | Santos Laguna | 2:2 (0:0) | |
| 16:00 | CF América | - | Mazatlán FC | 3:0 (1:0) | ||
| 16:00 | Atlas Guadalajara | - | CF Monterrey | 3:1 (2:1) | ||
| 16:00 | UANL Tigres | - | Club León | 2:0 (1:0) | ||
| 12.09.2021 | 16:00 | Gallos Blancos | - | Club Necaxa | 2:2 (0:1) | |
| 16:00 | Pumas UNAM | - | Deportivo Guadalajara | 1:2 (1:1) | ||
| 13.09.2021 | 19:00 | CF Pachuca | - | Deportivo Toluca | 2:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 8 | 4 | 4 | 0 | 16:8 | 8 | 16 |
| 2 |
|
Club Tijuana | 8 | 4 | 3 | 1 | 13:7 | 6 | 15 |
| 3 |
|
Club Necaxa | 8 | 4 | 2 | 2 | 14:10 | 4 | 14 |
| 4 |
|
Deportivo Toluca | 8 | 4 | 2 | 2 | 12:9 | 3 | 14 |
| 5 |
|
Club León | 8 | 4 | 2 | 2 | 9:8 | 1 | 14 |
| 6 |
|
Gallos Blancos | 8 | 4 | 1 | 3 | 11:9 | 2 | 13 |
| 7 |
|
Santos Laguna | 8 | 3 | 3 | 2 | 12:11 | 1 | 12 |
| 8 |
|
CF Monterrey | 8 | 3 | 2 | 3 | 15:11 | 4 | 11 |
| 9 |
|
Puebla FC | 8 | 3 | 2 | 3 | 14:16 | -2 | 11 |
| 10 |
|
Deportivo Guadalajara | 8 | 3 | 2 | 3 | 10:13 | -3 | 11 |
| 11 |
|
CF Pachuca | 8 | 2 | 4 | 2 | 8:8 | 0 | 10 |
| 12 |
|
Cruz Azul | 8 | 2 | 4 | 2 | 6:6 | 0 | 10 |
| 13 |
|
Atlas Guadalajara | 8 | 3 | 1 | 4 | 9:11 | -2 | 10 |
| 14 |
|
UANL Tigres | 8 | 2 | 2 | 4 | 10:10 | 0 | 8 |
| 15 |
|
Atlético San Luis | 8 | 2 | 2 | 4 | 15:16 | -1 | 8 |
| 16 |
|
Pumas UNAM | 8 | 2 | 2 | 4 | 13:18 | -5 | 8 |
| 17 |
|
Mazatlán FC | 8 | 2 | 2 | 4 | 10:16 | -6 | 8 |
| 18 |
|
FC Juárez | 8 | 0 | 2 | 6 | 5:15 | -10 | 2 |
| Playoff |
