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| I | Club Tijuana | - | CF América | 1:0 (0:0) | ||
| V | CF América | - | Club Tijuana | 1:0 (0:0) | ||
| I: 12.05.2022 04:00 | V: 14.05.2022 16:00 | |||||
| I | UANL Tigres | - | Club León | 1:0 (1:0) | ||
| V | Club León | - | UANL Tigres | 3:3 (1:1) | ||
| I: 12.05.2022 18:00 | V: 15.05.2022 16:00 | Campeones: UANL Tigres | ||||
