 |
 |
|
|
| 02.08.2022 | 16:00 | Deportivo Toluca | - | Puebla FC | 1:2 (0:0) | |
| 23.08.2022 | 16:00 | Gallos Blancos | - | CF América | 1:3 (0:2) | |
| 24.08.2022 | 16:00 | Pumas UNAM | - | UANL Tigres | 1:1 (0:1) | |
| 25.08.2022 | 19:00 | CF Pachuca | - | Atlas Guadalajara | 3:2 (0:1) | |
| 26.08.2022 | 00:45 | Club Tijuana | - | Santos Laguna | 1:1 (1:1) | |
| 15.09.2022 | 16:00 | Cruz Azul | - | Club León | 1:1 (1:0) | |
| 23.09.2022 | 17:00 | FC Juárez | - | Atlético San Luis | 3:0 (1:0) | |
| 24.09.2022 | 16:00 | Club Necaxa | - | Mazatlán FC | 2:0 (2:0) | |
| 28.09.2022 | 16:00 | Deportivo Guadalajara | - | CF Monterrey | 3:0 (3:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 16 | 12 | 3 | 1 | 34:13 | 21 | 39 |
| 2 |
|
Atlas Guadalajara | 16 | 10 | 3 | 3 | 28:16 | 12 | 33 |
| 3 |
|
UANL Tigres | 16 | 9 | 5 | 2 | 24:12 | 12 | 32 |
| 4 |
|
CF América | 16 | 8 | 6 | 2 | 33:18 | 15 | 30 |
| 5 |
|
Pumas UNAM | 16 | 9 | 2 | 5 | 26:14 | 12 | 29 |
| 6 |
|
Club León | 16 | 8 | 3 | 5 | 29:25 | 4 | 27 |
| 7 |
|
Santos Laguna | 16 | 7 | 5 | 4 | 30:24 | 6 | 26 |
| 8 |
|
Puebla FC | 16 | 7 | 5 | 4 | 29:26 | 3 | 26 |
| 9 |
|
FC Juárez | 16 | 6 | 3 | 7 | 18:26 | -8 | 21 |
| 10 |
|
Deportivo Guadalajara | 16 | 4 | 7 | 5 | 22:20 | 2 | 19 |
| 11 |
|
Club Necaxa | 16 | 5 | 4 | 7 | 28:28 | 0 | 19 |
| 12 |
|
Cruz Azul | 16 | 5 | 2 | 9 | 16:20 | -4 | 17 |
| 13 |
|
Mazatlán FC | 16 | 5 | 2 | 9 | 26:32 | -6 | 17 |
| 14 |
|
Atlético San Luis | 16 | 5 | 1 | 10 | 23:43 | -20 | 16 |
| 15 |
|
CF Monterrey | 16 | 4 | 3 | 9 | 22:29 | -7 | 15 |
| 16 |
|
Deportivo Toluca | 16 | 3 | 3 | 10 | 13:27 | -14 | 12 |
| 17 |
|
Club Tijuana | 16 | 1 | 8 | 7 | 21:34 | -13 | 11 |
| 18 |
|
Gallos Blancos | 16 | 1 | 5 | 10 | 14:29 | -15 | 8 |
| Playoff |
