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| 12.02.2021 | 16:30 | NAC Breda | - | FC Eindhoven | 2:1 (2:1) | |
| 16:30 | AZ Alkmaar (J) | - | FC Utrecht (J) | 3:2 (2:1) | ||
| 13.02.2021 | 12:00 | Go Ahead Eagles | - | Telstar | 1:0 (1:0) | |
| 14:15 | De Graafschap | - | MVV | 1:0 (1:0) | ||
| 15.02.2021 | 18:45 | Jong Ajax | - | FC Dordrecht | 1:2 (0:0) | |
| 21:00 | SBV Excelsior | - | Roda JC Kerkrade | 1:3 (0:1) | ||
| 16.02.2021 | 18:45 | SC Cambuur | - | TOP Oss | 3:0 (1:0) | |
| 23.02.2021 | 21:00 | Jong PSV | - | Helmond Sport | 2:2 (0:0) | |
| 02.03.2021 | 16:30 | NEC Nijmegen | - | FC Den Bosch | 4:1 (1:0) | |
| 03.03.2021 | 18:45 | Almere City FC | - | FC Volendam | 1:2 (1:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Cambuur | 24 | 18 | 3 | 3 | 69:20 | 49 | 57 |
| 2 |
|
De Graafschap | 24 | 17 | 2 | 5 | 51:33 | 18 | 53 |
| 3 |
|
Almere City FC | 24 | 15 | 5 | 4 | 52:32 | 20 | 50 |
| 4 |
|
NAC Breda | 24 | 14 | 5 | 5 | 45:21 | 24 | 47 |
| 5 |
|
NEC Nijmegen | 24 | 13 | 5 | 6 | 44:28 | 16 | 44 |
| 6 |
|
Go Ahead Eagles | 24 | 13 | 5 | 6 | 33:18 | 15 | 44 |
| 7 |
|
FC Volendam | 24 | 11 | 7 | 6 | 50:31 | 19 | 40 |
| 8 |
|
Roda JC Kerkrade | 24 | 10 | 8 | 6 | 45:32 | 13 | 38 |
| 9 |
|
Telstar | 24 | 9 | 6 | 9 | 42:35 | 7 | 33 |
| 10 |
|
SBV Excelsior | 24 | 9 | 3 | 12 | 45:43 | 2 | 30 |
| 11 |
|
Helmond Sport | 24 | 7 | 9 | 8 | 34:37 | -3 | 30 |
| 12 |
|
Jong Ajax | 24 | 8 | 6 | 10 | 39:44 | -5 | 30 |
| 13 |
|
FC Utrecht (J) | 24 | 9 | 1 | 14 | 37:45 | -8 | 28 |
| 14 |
|
TOP Oss | 24 | 8 | 4 | 12 | 25:36 | -11 | 28 |
| 15 |
|
FC Eindhoven | 24 | 7 | 6 | 11 | 35:43 | -8 | 27 |
| 16 |
|
AZ Alkmaar (J) | 24 | 6 | 4 | 14 | 35:65 | -30 | 22 |
| 17 |
|
Jong PSV | 24 | 5 | 6 | 13 | 36:53 | -17 | 21 |
| 18 |
|
MVV | 24 | 5 | 5 | 14 | 25:52 | -27 | 20 |
| 19 |
|
FC Dordrecht | 24 | 4 | 3 | 17 | 21:63 | -42 | 15 |
| 20 |
|
FC Den Bosch | 24 | 2 | 7 | 15 | 27:59 | -32 | 13 |
| Ascenso | |
| Playoff |
