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| 05.02.2022 | 16:30 | FC Utrecht | - | SC Cambuur | 3:2 (2:2) | |
| 18:45 | Fortuna Sittard | - | sc Heerenveen | 2:0 (1:0) | ||
| 20:00 | PEC Zwolle | - | NEC Nijmegen | 1:1 (1:1) | ||
| 20:00 | PSV | - | AZ Alkmaar | 1:2 (1:1) | ||
| 21:00 | FC Twente | - | Vitesse | 3:0 (2:0) | ||
| 06.02.2022 | 12:15 | Feyenoord | - | Sparta Rotterdam | 4:0 (2:0) | |
| 14:30 | FC Groningen | - | Go Ahead Eagles | 2:1 (1:0) | ||
| 14:30 | Willem II | - | RKC Waalwijk | 3:1 (3:0) | ||
| 16:45 | AFC Ajax | - | Heracles Almelo | 3:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AFC Ajax | 21 | 16 | 3 | 2 | 64:5 | 59 | 51 |
| 2 |
|
PSV | 21 | 15 | 1 | 5 | 49:28 | 21 | 46 |
| 3 |
|
Feyenoord | 21 | 14 | 3 | 4 | 50:19 | 31 | 45 |
| 4 |
|
FC Twente | 21 | 12 | 5 | 4 | 34:22 | 12 | 41 |
| 5 |
|
AZ Alkmaar | 21 | 12 | 3 | 6 | 39:25 | 14 | 39 |
| 6 |
|
Vitesse | 21 | 11 | 3 | 7 | 27:31 | -4 | 36 |
| 7 |
|
FC Utrecht | 21 | 10 | 5 | 6 | 39:28 | 11 | 35 |
| 8 |
|
SC Cambuur | 21 | 9 | 3 | 9 | 35:43 | -8 | 30 |
| 9 |
|
NEC Nijmegen | 21 | 7 | 6 | 8 | 26:31 | -5 | 27 |
| 10 |
|
FC Groningen | 21 | 6 | 7 | 8 | 25:30 | -5 | 25 |
| 11 |
|
sc Heerenveen | 21 | 7 | 4 | 10 | 20:30 | -10 | 25 |
| 12 |
|
RKC Waalwijk | 21 | 5 | 7 | 9 | 24:34 | -10 | 22 |
| 13 |
|
Go Ahead Eagles | 21 | 6 | 4 | 11 | 21:34 | -13 | 22 |
| 14 |
|
Willem II | 21 | 6 | 3 | 12 | 21:40 | -19 | 21 |
| 15 |
|
Heracles Almelo | 21 | 5 | 5 | 11 | 22:30 | -8 | 20 |
| 16 |
|
Fortuna Sittard | 21 | 4 | 4 | 13 | 23:50 | -27 | 16 |
| 17 |
|
Sparta Rotterdam | 21 | 2 | 8 | 11 | 16:35 | -19 | 14 |
| 18 |
|
PEC Zwolle | 21 | 3 | 4 | 14 | 13:33 | -20 | 13 |
| Champions League | |
| CL Ronda previa | |
| EL Ronda previa | |
| ECL Ronda previa | |
| Playoff | |
| Playoff | |
| Descenso |
