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| 12.11.2021 | 19:30 | SSVg Velbert | - | Germania Ratingen 04/19 | 5:1 (2:1) | |
| 13.11.2021 | 18:00 | SC Union Nettetal | - | Sportfreunde Niederwenigern | 2:0 (2:0) | |
| 14.11.2021 | 14:30 | 1. FC Kleve | - | FSV Duisburg | 1:1 (1:0) | |
| 14:30 | Sportfreunde Baumberg | - | VfB 03 Hilden | 1:2 (0:1) | ||
| 15:00 | Cronenberger SC | - | TV Jahn Hiesfeld | 2:0 (1:0) | ||
| 15:00 | Schwarz-Weiß Essen | - | FC Kray | 1:1 (1:1) | ||
| 15:00 | TSV Meerbusch | - | 1. FC Mönchengladbach | 5:2 (2:2) | ||
| 15:00 | TVD Velbert | - | TuRU Düsseldorf | 4:2 (1:2) | ||
| 15:15 | SpVgg Sterkrade-Nord | - | DJK Teutonia St. Tönis | 2:3 (0:0) | ||
| 15:30 | SC Düsseldorf-West | - | SC Velbert | 2:0 (1:0) | ||
| 15:30 | 1. FC Bocholt | - | 1. FC Monheim | 6:1 (3:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSVg Velbert | 12 | 10 | 2 | 0 | 37:10 | 27 | 32 |
| 2 |
|
VfB 03 Hilden | 12 | 10 | 1 | 1 | 31:11 | 20 | 31 |
| 3 |
|
1. FC Bocholt | 12 | 8 | 3 | 1 | 42:11 | 31 | 27 |
| 4 |
|
1. FC Kleve | 13 | 7 | 4 | 2 | 22:14 | 8 | 25 |
| 5 |
|
Germania Ratingen 04/19 | 13 | 7 | 2 | 4 | 33:23 | 10 | 23 |
| 6 |
|
1. FC Monheim | 13 | 7 | 2 | 4 | 24:17 | 7 | 23 |
| 7 |
|
SpVg Schonnebeck | 12 | 6 | 4 | 2 | 29:16 | 13 | 22 |
| 8 |
|
TSV Meerbusch | 12 | 7 | 0 | 5 | 26:24 | 2 | 21 |
| 9 |
|
TVD Velbert | 12 | 6 | 1 | 5 | 20:20 | 0 | 19 |
| 10 |
|
Sportfreunde Baumberg | 13 | 6 | 0 | 7 | 23:23 | 0 | 18 |
| 11 |
|
TuRU Düsseldorf | 13 | 5 | 2 | 6 | 20:25 | -5 | 17 |
| 12 |
|
SC Union Nettetal | 13 | 5 | 1 | 7 | 19:22 | -3 | 16 |
| 13 |
|
Schwarz-Weiß Essen | 12 | 5 | 1 | 6 | 19:26 | -7 | 16 |
| 14 |
|
FC Kray | 13 | 4 | 3 | 6 | 19:30 | -11 | 15 |
| 15 |
|
DJK Teutonia St. Tönis | 13 | 4 | 2 | 7 | 19:27 | -8 | 14 |
| 16 |
|
Sportfreunde Niederwenigern | 12 | 3 | 5 | 4 | 18:26 | -8 | 14 |
| 17 |
|
SC Velbert | 12 | 3 | 4 | 5 | 19:18 | 1 | 13 |
| 18 |
|
Cronenberger SC | 13 | 3 | 4 | 6 | 15:29 | -14 | 13 |
| 19 |
|
TV Jahn Hiesfeld | 12 | 3 | 2 | 7 | 15:20 | -5 | 11 |
| 20 |
|
SC Düsseldorf-West | 13 | 3 | 2 | 8 | 16:29 | -13 | 11 |
| 21 |
|
1. FC Mönchengladbach | 12 | 3 | 1 | 8 | 16:35 | -19 | 10 |
| 22 |
|
FSV Duisburg | 12 | 2 | 3 | 7 | 13:18 | -5 | 9 |
| 23 |
|
SpVgg Sterkrade-Nord | 12 | 1 | 1 | 10 | 15:36 | -21 | 4 |
| Playoff | |
| Playoff |
