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| 31.10.2021 | 15:00 | Westfalia Rhynern | - | TuS Haltern | 3:1 (2:1) | |
| 15:00 | SG Finnentrop/Bamenohl | - | Sportfreunde Siegen | 2:3 (1:3) | ||
| 15:00 | Viktoria Clarholz | - | TSG Sprockhövel | 1:0 (0:0) | ||
| 15:00 | 1. FC Kaan-Marienborn | - | Hammer SpVg | 3:0 (1:0) | ||
| 15:00 | RSV Meinerzhagen | - | Preußen Münster II | 2:1 (1:0) | ||
| 15:00 | Holzwickeder SC | - | FC Gütersloh | 1:3 (0:1) | ||
| 15:00 | ASC 09 Dortmund | - | SpVgg Vreden | 4:2 (3:0) | ||
| 15:15 | SV Schermbeck | - | SG Wattenscheid 09 | 1:2 (0:2) | ||
| 15:15 | Westfalia Herne | - | TuS Erndtebrück | 2:4 (0:1) | ||
| 15:15 | TuS Ennepetal | - | FCE Rheine | 4:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Kaan-Marienborn | 9 | 8 | 1 | 0 | 31:7 | 24 | 25 |
| 2 |
|
SG Wattenscheid 09 | 10 | 8 | 0 | 2 | 19:11 | 8 | 24 |
| 3 |
|
SC Paderborn 07 II | 9 | 7 | 1 | 1 | 30:6 | 24 | 22 |
| 4 |
|
FC Gütersloh | 9 | 6 | 2 | 1 | 17:8 | 9 | 20 |
| 5 |
|
Westfalia Rhynern | 10 | 6 | 0 | 4 | 29:16 | 13 | 18 |
| 6 |
|
ASC 09 Dortmund | 10 | 5 | 3 | 2 | 24:16 | 8 | 18 |
| 7 |
|
FCE Rheine | 10 | 6 | 0 | 4 | 14:16 | -2 | 18 |
| 8 |
|
Sportfreunde Siegen | 10 | 4 | 3 | 3 | 15:15 | 0 | 15 |
| 9 |
|
TuS Erndtebrück | 9 | 4 | 3 | 2 | 15:16 | -1 | 15 |
| 10 |
|
TSG Sprockhövel | 10 | 4 | 2 | 4 | 24:18 | 6 | 14 |
| 11 |
|
TuS Ennepetal | 9 | 4 | 2 | 3 | 17:15 | 2 | 14 |
| 12 |
|
TuS Haltern | 9 | 3 | 3 | 3 | 13:16 | -3 | 12 |
| 13 |
|
SV Schermbeck | 9 | 3 | 2 | 4 | 16:13 | 3 | 11 |
| 14 |
|
SpVgg Vreden | 10 | 3 | 2 | 5 | 11:25 | -14 | 11 |
| 15 |
|
Preußen Münster II | 9 | 3 | 1 | 5 | 13:19 | -6 | 10 |
| 16 |
|
Viktoria Clarholz | 9 | 2 | 2 | 5 | 11:16 | -5 | 8 |
| 17 |
|
Hammer SpVg | 10 | 2 | 2 | 6 | 16:23 | -7 | 8 |
| 18 |
|
Holzwickeder SC | 10 | 2 | 1 | 7 | 10:25 | -15 | 7 |
| 19 |
|
SG Finnentrop/Bamenohl | 9 | 1 | 3 | 5 | 12:24 | -12 | 6 |
| 20 |
|
RSV Meinerzhagen | 10 | 2 | 0 | 8 | 11:23 | -12 | 6 |
| 21 |
|
Westfalia Herne | 10 | 0 | 1 | 9 | 8:28 | -20 | 1 |
| Playoff | |
| Permanencia |
