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| I | Veraguas Club Deportivo | - | Herrera FC | 1:1 (1:1) | ||
| V | Herrera FC | - | Veraguas Club Deportivo | 1:0 (0:0) | ||
| I: 28.11.2021 01:00 | V: 06.12.2021 00:00 | Campeones: Herrera FC | ||||
| I | Alianza | - | Tauro FC | 0:0 (0:0) | ||
| V | Tauro FC | - | Alianza | 1:0 (1:0) | ||
| I: 30.11.2021 01:00 | V: 05.12.2021 23:00 | Campeones: Tauro FC | ||||
