 |
 |
|
|
| 14.05.2022 | 02:00 | Club Nacional | - | General Caballero DJLM | 1:2 (0:1) | |
| 22:00 | Guaireña FC | - | Resistencia SC | 0:0 (0:0) | ||
| 15.05.2022 | 01:15 | Sol de América | - | Cerro Porteño | 2:1 (1:1) | |
| 23:00 | Sportivo Ameliano | - | Libertad | 1:3 (0:1) | ||
| 16.05.2022 | 01:15 | Tacuary | - | Club Olimpia | 1:4 (0:0) | |
| 17.05.2022 | 02:00 | Guaraní | - | 12 de Octubre de Itauguá | 3:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Libertad | 16 | 13 | 2 | 1 | 37:13 | 24 | 41 |
| 2 |
|
Cerro Porteño | 16 | 11 | 2 | 3 | 28:11 | 17 | 35 |
| 3 |
|
Club Olimpia | 16 | 9 | 3 | 4 | 24:15 | 9 | 30 |
| 4 |
|
Resistencia SC | 16 | 7 | 6 | 3 | 28:22 | 6 | 27 |
| 5 |
|
Guaraní | 16 | 6 | 3 | 7 | 21:20 | 1 | 21 |
| 6 |
|
Sol de América | 16 | 6 | 3 | 7 | 17:21 | -4 | 21 |
| 7 |
|
Club Nacional | 16 | 6 | 2 | 8 | 20:26 | -6 | 20 |
| 8 |
|
Guaireña FC | 16 | 4 | 5 | 7 | 13:19 | -6 | 17 |
| 9 |
|
Tacuary | 16 | 5 | 2 | 9 | 13:21 | -8 | 17 |
| 10 |
|
General Caballero DJLM | 16 | 3 | 4 | 9 | 14:22 | -8 | 13 |
| 11 |
|
Sportivo Ameliano | 16 | 4 | 1 | 11 | 18:28 | -10 | 13 |
| 12 |
|
12 de Octubre de Itauguá | 16 | 2 | 7 | 7 | 13:28 | -15 | 13 |
| Copa Libertadores |
