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| 06.02.2021 | 14:00 | Colonia | - | SV Lippstadt 08 | 2:1 (2:1) | |
| 14:00 | Alemannia Aachen | - | Fortuna Düsseldorf II | 0:2 (0:0) | ||
| 14:00 | FC Wegberg-Beeck | - | Bonner SC | 0:2 (0:0) | ||
| 14:00 | Sportfreunde Lotte | - | Rot Weiss Ahlen | 1:1 (1:0) | ||
| 14:00 | SV Bergisch Gladbach 09 | - | Rot-Weiß Oberhausen | 0:2 (0:1) | ||
| 14:00 | SV Rödinghausen | - | Schalke II | 2:1 (1:0) | ||
| 14:00 | SV 19 Straelen | - | Bor. Mönchengladbach II | 1:2 (0:1) | ||
| 14:00 | VfB Homberg | - | Preußen Münster | 0:1 (0:0) | ||
| 03.03.2021 | 18:00 | Wuppertaler SV | - | Fortuna Köln | 2:0 (1:0) | |
| 17.03.2021 | 19:30 | Rot-Weiss Essen | - | Borussia Dortmund II | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 24 | 17 | 6 | 1 | 63:17 | 46 | 57 |
| 2 |
|
Rot-Weiss Essen | 23 | 16 | 7 | 0 | 49:13 | 36 | 55 |
| 3 |
|
Preußen Münster | 24 | 14 | 4 | 6 | 35:20 | 15 | 46 |
| 4 |
|
Fortuna Köln | 24 | 12 | 8 | 4 | 44:25 | 19 | 44 |
| 5 |
|
Fortuna Düsseldorf II | 24 | 12 | 5 | 7 | 47:26 | 21 | 41 |
| 6 |
|
Colonia | 23 | 10 | 8 | 5 | 35:26 | 9 | 38 |
| 7 |
|
Bor. Mönchengladbach II | 24 | 11 | 5 | 8 | 35:29 | 6 | 38 |
| 8 |
|
SV Rödinghausen | 24 | 11 | 5 | 8 | 33:27 | 6 | 38 |
| 9 |
|
Schalke II | 24 | 8 | 10 | 6 | 29:24 | 5 | 34 |
| 10 |
|
Rot-Weiß Oberhausen | 24 | 8 | 9 | 7 | 36:31 | 5 | 33 |
| 11 |
|
Alemannia Aachen | 24 | 8 | 7 | 9 | 19:21 | -2 | 31 |
| 12 |
|
SC Wiedenbrück | 23 | 6 | 11 | 6 | 31:32 | -1 | 29 |
| 13 |
|
SV 19 Straelen | 24 | 7 | 7 | 10 | 27:39 | -12 | 28 |
| 14 |
|
Wuppertaler SV | 24 | 8 | 4 | 12 | 29:42 | -13 | 28 |
| 15 |
|
SV Lippstadt 08 | 24 | 5 | 10 | 9 | 27:39 | -12 | 25 |
| 16 |
|
FC Wegberg-Beeck | 24 | 6 | 7 | 11 | 24:36 | -12 | 25 |
| 17 |
|
VfB Homberg | 24 | 6 | 4 | 14 | 22:43 | -21 | 22 |
| 18 |
|
SV Bergisch Gladbach 09 | 24 | 4 | 6 | 14 | 20:44 | -24 | 18 |
| 19 |
|
Sportfreunde Lotte | 23 | 4 | 6 | 13 | 19:46 | -27 | 18 |
| 20 |
|
Bonner SC | 24 | 4 | 4 | 16 | 22:46 | -24 | 16 |
| 21 |
|
Rot Weiss Ahlen | 24 | 2 | 9 | 13 | 26:46 | -20 | 15 |
| Ascenso | |
| Descenso |
