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| 06.04.2019 | 13:00 | Anzhi Makhachkala | - | Dinamo Moskva | 1:1 (1:0) | |
| 15:30 | FK Krasnodar | - | Krylia Sovetov | 1:0 (0:0) | ||
| 18:00 | Spartak Moskva | - | CSKA Moscú | 0:2 (0:0) | ||
| 07.04.2019 | 10:30 | FK Ufa | - | FK Rostov | 1:0 (1:0) | |
| 13:00 | FK Ural | - | Enisey Krasnoyarsk | 3:2 (0:1) | ||
| 15:30 | Rubin Kazan | - | Arsenal Tula | 0:0 (0:0) | ||
| 18:00 | Lokomotiv Moskva | - | Zenit | 1:1 (0:0) | ||
| 08.04.2019 | 16:00 | FK Orenburg | - | Akhmat Grozny | 1:3 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 22 | 14 | 3 | 5 | 35:21 | 14 | 45 |
| 2 |
|
FK Krasnodar | 22 | 12 | 5 | 5 | 40:17 | 23 | 41 |
| 3 |
|
CSKA Moscú | 22 | 11 | 7 | 4 | 31:12 | 19 | 40 |
| 4 |
|
Lokomotiv Moskva | 22 | 11 | 6 | 5 | 30:20 | 10 | 39 |
| 5 |
|
Spartak Moskva | 22 | 10 | 6 | 6 | 28:22 | 6 | 36 |
| 6 |
|
FK Rostov | 22 | 8 | 8 | 6 | 19:14 | 5 | 32 |
| 7 |
|
Arsenal Tula | 22 | 8 | 7 | 7 | 28:25 | 3 | 31 |
| 8 |
|
Rubin Kazan | 22 | 6 | 12 | 4 | 19:20 | -1 | 30 |
| 9 |
|
Akhmat Grozny | 22 | 8 | 6 | 8 | 21:23 | -2 | 30 |
| 10 |
|
FK Orenburg | 22 | 8 | 5 | 9 | 25:25 | 0 | 29 |
| 11 |
|
FK Ural | 22 | 7 | 5 | 10 | 23:35 | -12 | 26 |
| 12 |
|
Dinamo Moskva | 22 | 5 | 9 | 8 | 19:18 | 1 | 24 |
| 13 |
|
Krylia Sovetov | 22 | 7 | 3 | 12 | 19:29 | -10 | 24 |
| 14 |
|
FK Ufa | 22 | 4 | 8 | 10 | 17:25 | -8 | 20 |
| 15 |
|
Anzhi Makhachkala | 22 | 5 | 4 | 13 | 11:35 | -24 | 19 |
| 16 |
|
Enisey Krasnoyarsk | 22 | 2 | 6 | 14 | 15:39 | -24 | 12 |
| Champions League | |
| CL Ronda previa | |
| Europa League | |
| EL Ronda previa | |
| Permanencia | |
| Descenso |
