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| 26.02.2021 | 17:00 | FK Tambov | - | Rotor Volgograd | 1:3 (1:0) | |
| 27.02.2021 | 12:00 | FK Khimki | - | FK Ufa | 2:1 (0:0) | |
| 14:30 | Zenit | - | FK Rostov | 2:2 (0:1) | ||
| 17:00 | Lokomotiv Moskva | - | CSKA Moscú | 2:0 (2:0) | ||
| 17:00 | FK Sochi | - | Arsenal Tula | 4:0 (0:0) | ||
| 28.02.2021 | 12:00 | Spartak Moskva | - | Rubin Kazan | 0:2 (0:0) | |
| 14:30 | Akhmat Grozny | - | Dinamo Moskva | 1:2 (0:2) | ||
| 17:00 | FK Krasnodar | - | FK Ural | 2:2 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 20 | 12 | 6 | 2 | 45:17 | 28 | 42 |
| 2 |
|
CSKA Moscú | 20 | 11 | 4 | 5 | 35:19 | 16 | 37 |
| 3 |
|
FK Sochi | 20 | 10 | 6 | 4 | 32:22 | 10 | 36 |
| 4 |
|
Spartak Moskva | 20 | 10 | 5 | 5 | 33:23 | 10 | 35 |
| 5 |
|
Dinamo Moskva | 20 | 10 | 3 | 7 | 26:22 | 4 | 33 |
|
FK Rostov | 20 | 10 | 3 | 7 | 26:22 | 4 | 33 | |
| 7 |
|
FK Krasnodar | 20 | 9 | 4 | 7 | 37:21 | 16 | 31 |
| 8 |
|
Lokomotiv Moskva | 20 | 9 | 4 | 7 | 23:25 | -2 | 31 |
| 9 |
|
Rubin Kazan | 20 | 9 | 4 | 7 | 26:25 | 1 | 31 |
| 10 |
|
FK Khimki | 20 | 8 | 4 | 8 | 26:31 | -5 | 28 |
| 11 |
|
Akhmat Grozny | 20 | 7 | 5 | 8 | 20:23 | -3 | 26 |
| 12 |
|
FK Ural | 20 | 4 | 10 | 6 | 18:25 | -7 | 22 |
| 13 |
|
Rotor Volgograd | 20 | 4 | 5 | 11 | 12:31 | -19 | 17 |
| 14 |
|
Arsenal Tula | 20 | 3 | 5 | 12 | 17:34 | -17 | 14 |
| 15 |
|
FK Ufa | 20 | 3 | 4 | 13 | 15:33 | -18 | 13 |
| 16 |
|
FK Tambov | 20 | 3 | 4 | 13 | 14:32 | -18 | 13 |
| Champions League | |
| CL Ronda previa | |
| EL Ronda previa | |
| Permanencia | |
| Descenso |
