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| 07.05.2021 | 17:00 | Akhmat Grozny | - | FK Tambov | 3:1 (2:0) | |
| 19:00 | FK Sochi | - | Rotor Volgograd | 2:1 (1:1) | ||
| 08.05.2021 | 13:00 | FK Ufa | - | Zenit | 0:0 (0:0) | |
| 15:30 | Arsenal Tula | - | Rubin Kazan | 2:4 (2:0) | ||
| 15:30 | Lokomotiv Moskva | - | Dinamo Moskva | 0:0 (0:0) | ||
| 18:30 | CSKA Moscú | - | FK Krasnodar | 3:1 (1:1) | ||
| 10.05.2021 | 15:30 | FK Ural | - | FK Rostov | 1:0 (1:0) | |
| 18:00 | Spartak Moskva | - | FK Khimki | 2:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 29 | 18 | 8 | 3 | 71:25 | 46 | 62 |
| 2 |
|
Spartak Moskva | 29 | 17 | 5 | 7 | 54:35 | 19 | 56 |
| 3 |
|
Lokomotiv Moskva | 29 | 16 | 5 | 8 | 44:35 | 9 | 53 |
| 4 |
|
Rubin Kazan | 29 | 16 | 4 | 9 | 41:32 | 9 | 52 |
| 5 |
|
FK Sochi | 29 | 15 | 7 | 7 | 49:33 | 16 | 52 |
| 6 |
|
CSKA Moscú | 29 | 15 | 5 | 9 | 49:30 | 19 | 50 |
| 7 |
|
Dinamo Moskva | 29 | 14 | 5 | 10 | 41:31 | 10 | 47 |
| 8 |
|
FK Khimki | 29 | 13 | 5 | 11 | 35:39 | -4 | 44 |
| 9 |
|
FK Rostov | 29 | 13 | 4 | 12 | 36:32 | 4 | 43 |
| 10 |
|
Akhmat Grozny | 29 | 11 | 6 | 12 | 34:36 | -2 | 39 |
| 11 |
|
FK Krasnodar | 29 | 11 | 5 | 13 | 49:44 | 5 | 38 |
| 12 |
|
FK Ural | 29 | 7 | 13 | 9 | 26:35 | -9 | 34 |
| 13 |
|
Arsenal Tula | 29 | 6 | 5 | 18 | 27:49 | -22 | 23 |
| 14 |
|
FK Ufa | 29 | 5 | 7 | 17 | 24:45 | -21 | 22 |
| 15 |
|
Rotor Volgograd | 29 | 5 | 6 | 18 | 14:51 | -37 | 21 |
| 16 |
|
FK Tambov | 29 | 3 | 4 | 22 | 18:60 | -42 | 13 |
| Champions League | |
| CL Ronda previa | |
| EL Ronda previa | |
| Permanencia | |
| Descenso |
