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| 03.12.2021 | 17:00 | Zenit | - | FK Rostov | 2:2 (1:2) | |
| 04.12.2021 | 12:00 | Krylia Sovetov | - | CSKA Moscú | 0:1 (0:0) | |
| 15:00 | Spartak Moskva | - | Akhmat Grozny | 2:1 (1:1) | ||
| 17:00 | Lokomotiv Moskva | - | FK Ural | 0:1 (0:1) | ||
| 05.12.2021 | 12:00 | FK Khimki | - | Arsenal Tula | 1:2 (1:0) | |
| 14:30 | Dinamo Moskva | - | FK Ufa | 2:0 (1:0) | ||
| 14:30 | FK Nizhny Novgorod | - | Rubin Kazan | 2:1 (2:1) | ||
| 17:00 | FK Sochi | - | FK Krasnodar | 1:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit | 17 | 11 | 4 | 2 | 43:19 | 24 | 37 |
| 2 |
|
Dinamo Moskva | 17 | 11 | 2 | 4 | 32:19 | 13 | 35 |
| 3 |
|
FK Sochi | 17 | 9 | 1 | 7 | 27:21 | 6 | 28 |
| 4 |
|
FK Krasnodar | 17 | 8 | 4 | 5 | 29:18 | 11 | 28 |
| 5 |
|
CSKA Moscú | 17 | 8 | 3 | 6 | 19:16 | 3 | 27 |
| 6 |
|
Lokomotiv Moskva | 17 | 6 | 7 | 4 | 22:19 | 3 | 25 |
| 7 |
|
Krylia Sovetov | 17 | 7 | 3 | 7 | 20:18 | 2 | 24 |
| 8 |
|
Akhmat Grozny | 17 | 8 | 0 | 9 | 20:23 | -3 | 24 |
| 9 |
|
Spartak Moskva | 17 | 6 | 5 | 6 | 20:23 | -3 | 23 |
| 10 |
|
Rubin Kazan | 17 | 6 | 4 | 7 | 23:25 | -2 | 22 |
| 11 |
|
Arsenal Tula | 17 | 5 | 4 | 8 | 21:33 | -12 | 19 |
| 12 |
|
FK Rostov | 17 | 4 | 6 | 7 | 29:31 | -2 | 18 |
| 13 |
|
FK Nizhny Novgorod | 17 | 5 | 3 | 9 | 18:30 | -12 | 18 |
| 14 |
|
FK Ufa | 17 | 3 | 7 | 7 | 17:24 | -7 | 16 |
| 15 |
|
FK Ural | 17 | 3 | 7 | 7 | 8:17 | -9 | 16 |
| 16 |
|
FK Khimki | 17 | 2 | 8 | 7 | 15:27 | -12 | 14 |
| Permanencia | |
| Descenso |
