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| 23.05.2021 | 12:00 | Lokomotiv Moskva | - | PFC Sochi | 4:1 (3:0) | |
| 12:00 | FK Strogino Moskva | - | FK Rostov | 1:2 (1:1) | ||
| 13:30 | Rubin Kazan | - | Akhmat Grozny | 0:0 (0:0) | ||
| 17:00 | Zenit St. Petersburg | - | FK Krasnodar | 1:0 (0:0) | ||
| 17:00 | CSKA Moskva | - | Spartak Moskva | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CSKA Moskva | 27 | 21 | 2 | 4 | 76:26 | 50 | 65 |
| 2 |
|
Zenit St. Petersburg | 27 | 20 | 2 | 5 | 67:27 | 40 | 62 |
| 3 |
|
FK Krasnodar | 27 | 19 | 4 | 4 | 56:21 | 35 | 61 |
| 4 |
|
Spartak Moskva | 27 | 16 | 7 | 4 | 52:26 | 26 | 55 |
| 5 |
|
Lokomotiv Moskva | 27 | 15 | 5 | 7 | 50:22 | 28 | 50 |
| 6 |
|
Akhmat Grozny | 27 | 13 | 7 | 7 | 46:42 | 4 | 46 |
| 7 |
|
FK Rostov | 27 | 11 | 7 | 9 | 44:38 | 6 | 40 |
| 8 |
|
Rubin Kazan | 27 | 9 | 9 | 9 | 30:30 | 0 | 36 |
| 9 |
|
FK Strogino Moskva | 27 | 9 | 4 | 14 | 44:53 | -9 | 31 |
| 10 |
|
PFC Sochi | 27 | 7 | 8 | 12 | 30:37 | -7 | 29 |
