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| 22.10.2021 | 19:00 | MKE Ankaragücü | - | Manisa FK | 2:1 (2:0) | |
| 19:00 | Eyüpspor | - | Adanaspor | 1:0 (0:0) | ||
| 23.10.2021 | 12:30 | Keçiörengücü | - | İstanbulspor AŞ | 3:2 (1:0) | |
| 15:00 | Tuzlaspor | - | Bandırmaspor | 0:3 (0:2) | ||
| 18:00 | Boluspor | - | Menemen Belediyespor | 1:0 (0:0) | ||
| 18:00 | Samsunspor | - | BB Erzurumspor | 0:0 (0:0) | ||
| 24.10.2021 | 12:30 | Altınordu FK | - | Ümraniyespor | 0:2 (0:2) | |
| 15:00 | Balıkesirspor | - | Bursaspor | 0:2 (0:1) | ||
| 18:00 | Kocaelispor | - | Gençlerbirliği | 1:2 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 10 | 7 | 3 | 0 | 19:6 | 13 | 24 |
| 2 |
|
Ümraniyespor | 10 | 7 | 3 | 0 | 19:3 | 16 | 24 |
| 3 |
|
Eyüpspor | 10 | 6 | 2 | 2 | 17:12 | 5 | 20 |
| 4 |
|
BB Erzurumspor | 10 | 6 | 1 | 3 | 15:10 | 5 | 19 |
| 5 |
|
Bandırmaspor | 10 | 6 | 0 | 4 | 18:10 | 8 | 18 |
| 6 |
|
Kocaelispor | 9 | 5 | 1 | 3 | 9:9 | 0 | 16 |
| 7 |
|
Tuzlaspor | 9 | 4 | 2 | 3 | 9:8 | 1 | 14 |
| 8 |
|
Gençlerbirliği | 9 | 4 | 2 | 3 | 12:14 | -2 | 14 |
| 9 |
|
Samsunspor | 9 | 3 | 3 | 3 | 14:14 | 0 | 12 |
| 10 |
|
Boluspor | 9 | 3 | 2 | 4 | 9:9 | 0 | 11 |
| 11 |
|
Bursaspor | 9 | 3 | 2 | 4 | 12:13 | -1 | 11 |
| 12 |
|
Menemen Belediyespor | 10 | 3 | 2 | 5 | 12:18 | -6 | 11 |
| 13 |
|
İstanbulspor AŞ | 9 | 3 | 1 | 5 | 12:13 | -1 | 10 |
| 14 |
|
Denizlispor | 9 | 3 | 1 | 5 | 9:12 | -3 | 10 |
| 15 |
|
Altınordu FK | 10 | 3 | 1 | 6 | 12:22 | -10 | 10 |
| 16 |
|
Manisa FK | 10 | 3 | 0 | 7 | 12:18 | -6 | 9 |
| 17 |
|
Adanaspor | 10 | 2 | 3 | 5 | 12:16 | -4 | 9 |
| 18 |
|
Keçiörengücü | 9 | 2 | 1 | 6 | 8:14 | -6 | 7 |
| 19 |
|
Balıkesirspor | 9 | 2 | 0 | 7 | 6:15 | -9 | 6 |
| Ascenso | |
| Playoff | |
| Descenso |
