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| 14.12.2021 | 11:30 | BB Erzurumspor | - | Gençlerbirliği | 2:0 (0:0) | |
| 11:30 | Manisa FK | - | Keçiörengücü | 1:1 (0:0) | ||
| 17:00 | Altınordu FK | - | Kocaelispor | 3:2 (1:2) | ||
| 15.12.2021 | 11:30 | Bandırmaspor | - | Balıkesirspor | 3:0 (0:0) | |
| 14:00 | Samsunspor | - | Boluspor | 1:1 (1:1) | ||
| 17:00 | Eyüpspor | - | Tuzlaspor | 2:0 (0:0) | ||
| 17:00 | Menemen Belediyespor | - | Denizlispor | 0:0 (0:0) | ||
| 16.12.2021 | 11:30 | Ümraniyespor | - | Bursaspor | 4:1 (1:0) | |
| 17:00 | Adanaspor | - | İstanbulspor AŞ | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 16 | 10 | 3 | 3 | 30:14 | 16 | 33 |
| 2 |
|
BB Erzurumspor | 16 | 10 | 2 | 4 | 26:17 | 9 | 32 |
| 3 |
|
Eyüpspor | 16 | 9 | 3 | 4 | 27:20 | 7 | 30 |
| 4 |
|
MKE Ankaragücü | 16 | 9 | 3 | 4 | 25:13 | 12 | 30 |
| 5 |
|
Bandırmaspor | 16 | 9 | 1 | 6 | 27:15 | 12 | 28 |
| 6 |
|
Samsunspor | 16 | 7 | 5 | 4 | 23:19 | 4 | 26 |
| 7 |
|
İstanbulspor AŞ | 16 | 7 | 2 | 7 | 25:23 | 2 | 23 |
| 8 |
|
Tuzlaspor | 16 | 6 | 5 | 5 | 17:15 | 2 | 23 |
| 9 |
|
Kocaelispor | 16 | 7 | 2 | 7 | 18:19 | -1 | 23 |
| 10 |
|
Gençlerbirliği | 16 | 7 | 2 | 7 | 17:22 | -5 | 23 |
| 11 |
|
Adanaspor | 17 | 6 | 5 | 6 | 18:19 | -1 | 23 |
| 12 |
|
Boluspor | 16 | 5 | 6 | 5 | 19:17 | 2 | 21 |
| 13 |
|
Menemen Belediyespor | 16 | 5 | 5 | 6 | 21:26 | -5 | 20 |
| 14 |
|
Manisa FK | 17 | 5 | 4 | 8 | 19:24 | -5 | 19 |
| 15 |
|
Bursaspor | 16 | 5 | 3 | 8 | 22:27 | -5 | 18 |
| 16 |
|
Keçiörengücü | 16 | 5 | 3 | 8 | 20:25 | -5 | 18 |
| 17 |
|
Denizlispor | 16 | 4 | 4 | 8 | 14:22 | -8 | 16 |
| 18 |
|
Altınordu FK | 16 | 5 | 1 | 10 | 18:31 | -13 | 16 |
| 19 |
|
Balıkesirspor | 16 | 2 | 1 | 13 | 10:28 | -18 | 7 |
| Ascenso | |
| Playoff | |
| Descenso |
