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| 08.05.2022 | 15:00 | Balıkesirspor | - | Bandırmaspor | 1:5 (1:3) | |
| 15:00 | Boluspor | - | Samsunspor | 2:1 (1:1) | ||
| 15:00 | Bursaspor | - | Ümraniyespor | 3:2 (1:1) | ||
| 15:00 | Denizlispor | - | Menemen Belediyespor | 2:1 (1:1) | ||
| 15:00 | Gençlerbirliği | - | BB Erzurumspor | 2:1 (1:1) | ||
| 15:00 | İstanbulspor AŞ | - | Adanaspor | 1:1 (1:0) | ||
| 15:00 | Keçiörengücü | - | Manisa FK | 2:1 (1:1) | ||
| 15:00 | Kocaelispor | - | Altınordu FK | 2:2 (1:0) | ||
| 15:00 | Tuzlaspor | - | Eyüpspor | 3:2 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 34 | 20 | 7 | 7 | 53:28 | 25 | 67 |
| 2 |
|
Ümraniyespor | 34 | 20 | 6 | 8 | 60:35 | 25 | 66 |
| 3 |
|
Bandırmaspor | 34 | 18 | 4 | 12 | 52:32 | 20 | 58 |
| 4 |
|
İstanbulspor AŞ | 34 | 17 | 7 | 10 | 57:40 | 17 | 58 |
| 5 |
|
BB Erzurumspor | 34 | 16 | 9 | 9 | 53:38 | 15 | 57 |
| 6 |
|
Eyüpspor | 34 | 13 | 12 | 9 | 51:43 | 8 | 51 |
| 7 |
|
Tuzlaspor | 34 | 13 | 10 | 11 | 42:36 | 6 | 49 |
| 8 |
|
Samsunspor | 34 | 12 | 11 | 11 | 50:44 | 6 | 47 |
| 9 |
|
Keçiörengücü | 34 | 13 | 8 | 13 | 42:43 | -1 | 47 |
| 10 |
|
Manisa FK | 35 | 13 | 7 | 15 | 41:43 | -2 | 46 |
| 11 |
|
Denizlispor | 34 | 13 | 6 | 15 | 42:50 | -8 | 45 |
| 12 |
|
Gençlerbirliği | 34 | 13 | 6 | 15 | 39:49 | -10 | 45 |
| 13 |
|
Adanaspor | 35 | 12 | 9 | 14 | 39:40 | -1 | 45 |
| 14 |
|
Boluspor | 34 | 12 | 8 | 14 | 38:42 | -4 | 44 |
| 15 |
|
Altınordu FK | 34 | 13 | 3 | 18 | 42:59 | -17 | 42 |
| 16 |
|
Bursaspor | 34 | 11 | 8 | 15 | 40:49 | -9 | 41 |
| 17 |
|
Kocaelispor | 34 | 11 | 8 | 15 | 35:46 | -11 | 41 |
| 18 |
|
Menemen Belediyespor | 34 | 8 | 14 | 12 | 41:53 | -12 | 38 |
| 19 |
|
Balıkesirspor | 34 | 3 | 3 | 28 | 25:72 | -47 | 12 |
| Ascenso | |
| Playoff | |
| Descenso |
