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| 01.10.2021 | 19:00 | Altınordu FK | - | Menemen Belediyespor | 1:0 (1:0) | |
| 02.10.2021 | 12:30 | Tuzlaspor | - | Keçiörengücü | 1:0 (0:0) | |
| 15:00 | Balıkesirspor | - | Gençlerbirliği | 0:2 (0:1) | ||
| 18:00 | Adanaspor | - | Bandırmaspor | 1:5 (1:0) | ||
| 18:00 | Kocaelispor | - | İstanbulspor AŞ | 2:1 (1:1) | ||
| 03.10.2021 | 12:30 | Boluspor | - | Denizlispor | 0:0 (0:0) | |
| 15:00 | Samsunspor | - | Ümraniyespor | 1:1 (0:0) | ||
| 18:00 | MKE Ankaragücü | - | BB Erzurumspor | 2:1 (1:0) | ||
| 18:00 | Eyüpspor | - | Manisa FK | 3:2 (1:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Ümraniyespor | 8 | 6 | 2 | 0 | 15:1 | 14 | 20 |
| 2 |
|
MKE Ankaragücü | 8 | 5 | 3 | 0 | 15:4 | 11 | 18 |
| 3 |
|
Eyüpspor | 8 | 5 | 1 | 2 | 14:10 | 4 | 16 |
| 4 |
|
Bandırmaspor | 8 | 5 | 0 | 3 | 14:8 | 6 | 15 |
| 5 |
|
BB Erzurumspor | 8 | 5 | 0 | 3 | 9:8 | 1 | 15 |
| 6 |
|
Tuzlaspor | 7 | 4 | 2 | 1 | 9:4 | 5 | 14 |
| 7 |
|
Kocaelispor | 7 | 4 | 1 | 2 | 7:7 | 0 | 13 |
| 8 |
|
Samsunspor | 7 | 3 | 2 | 2 | 12:11 | 1 | 11 |
| 9 |
|
Gençlerbirliği | 8 | 3 | 2 | 3 | 10:13 | -3 | 11 |
| 10 |
|
Altınordu FK | 8 | 3 | 1 | 4 | 10:14 | -4 | 10 |
| 11 |
|
Manisa FK | 8 | 3 | 0 | 5 | 11:13 | -2 | 9 |
| 12 |
|
Boluspor | 7 | 2 | 2 | 3 | 7:6 | 1 | 8 |
| 13 |
|
Menemen Belediyespor | 8 | 2 | 2 | 4 | 9:15 | -6 | 8 |
| 14 |
|
İstanbulspor AŞ | 7 | 2 | 1 | 4 | 9:10 | -1 | 7 |
| 15 |
|
Denizlispor | 8 | 2 | 1 | 5 | 7:11 | -4 | 7 |
| 16 |
|
Balıkesirspor | 7 | 2 | 0 | 5 | 5:11 | -6 | 6 |
| 17 |
|
Adanaspor | 8 | 1 | 3 | 4 | 9:15 | -6 | 6 |
| 18 |
|
Bursaspor | 7 | 1 | 2 | 4 | 7:12 | -5 | 5 |
| 19 |
|
Keçiörengücü | 7 | 1 | 1 | 5 | 5:11 | -6 | 4 |
| Ascenso | |
| Playoff | |
| Descenso |
