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| 10.12.2021 | 18:00 | Altay Izmir | - | Hatayspor | 1:2 (1:1) | |
| 11.12.2021 | 11:30 | Fatih Karagümrük SK | - | Konyaspor | 1:4 (1:1) | |
| 14:00 | Çaykur Rizespor | - | Göztepe | 3:1 (1:0) | ||
| 14:00 | İstanbul Başakşehir | - | Kasımpaşa SK | 2:1 (0:0) | ||
| 17:00 | Antalyaspor | - | Trabzonspor | 2:1 (1:1) | ||
| 12.12.2021 | 11:30 | Adana Demirspor | - | Giresunspor | 1:0 (0:0) | |
| 14:00 | Yeni Malatyaspor | - | Alanyaspor | 2:6 (2:3) | ||
| 17:00 | Beşiktaş | - | Kayserispor | 4:2 (1:1) | ||
| 13.12.2021 | 16:00 | Sivasspor | - | Galatasaray | 1:0 (0:0) | |
| 18:30 | Gaziantep FK | - | Fenerbahçe | 3:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 16 | 12 | 3 | 1 | 32:13 | 19 | 39 |
| 2 |
|
Konyaspor | 16 | 8 | 6 | 2 | 27:14 | 13 | 30 |
| 3 |
|
Hatayspor | 16 | 9 | 2 | 5 | 25:18 | 7 | 29 |
| 4 |
|
İstanbul Başakşehir | 16 | 9 | 1 | 6 | 25:17 | 8 | 28 |
| 5 |
|
Fenerbahçe | 16 | 8 | 3 | 5 | 26:20 | 6 | 27 |
| 6 |
|
Alanyaspor | 16 | 8 | 3 | 5 | 26:25 | 1 | 27 |
| 7 |
|
Beşiktaş | 16 | 7 | 3 | 6 | 26:24 | 2 | 24 |
| 8 |
|
Adana Demirspor | 16 | 6 | 5 | 5 | 21:20 | 1 | 23 |
|
Galatasaray | 16 | 6 | 5 | 5 | 21:20 | 1 | 23 | |
| 10 |
|
Sivasspor | 16 | 5 | 7 | 4 | 22:15 | 7 | 22 |
| 11 |
|
Fatih Karagümrük SK | 16 | 6 | 4 | 6 | 23:25 | -2 | 22 |
| 12 |
|
Antalyaspor | 16 | 6 | 3 | 7 | 20:23 | -3 | 21 |
| 13 |
|
Gaziantep FK | 16 | 6 | 3 | 7 | 21:25 | -4 | 21 |
| 14 |
|
Giresunspor | 16 | 5 | 4 | 7 | 15:14 | 1 | 19 |
| 15 |
|
Kayserispor | 16 | 5 | 4 | 7 | 22:26 | -4 | 19 |
| 16 |
|
Altay Izmir | 16 | 5 | 3 | 8 | 21:25 | -4 | 18 |
| 17 |
|
Göztepe | 16 | 3 | 5 | 8 | 16:24 | -8 | 14 |
| 18 |
|
Yeni Malatyaspor | 16 | 4 | 2 | 10 | 14:29 | -15 | 14 |
| 19 |
|
Çaykur Rizespor | 16 | 4 | 1 | 11 | 15:32 | -17 | 13 |
| 20 |
|
Kasımpaşa SK | 16 | 2 | 5 | 9 | 15:24 | -9 | 11 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
