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| 25.12.2021 | 11:30 | Kasımpaşa SK | - | Altay Izmir | 2:0 (1:0) | |
| 14:00 | Galatasaray | - | Antalyaspor | 2:0 (1:0) | ||
| 14:00 | Giresunspor | - | Hatayspor | 0:1 (0:0) | ||
| 17:00 | Trabzonspor | - | İstanbul Başakşehir | 0:0 (0:0) | ||
| 26.12.2021 | 11:30 | Çaykur Rizespor | - | Gaziantep FK | 0:1 (0:1) | |
| 14:00 | Alanyaspor | - | Fatih Karagümrük SK | 1:1 (0:0) | ||
| 14:00 | Göztepe | - | Adana Demirspor | 1:1 (0:1) | ||
| 17:00 | Fenerbahçe | - | Yeni Malatyaspor | 2:0 (1:0) | ||
| 27.12.2021 | 18:00 | Kayserispor | - | Sivasspor | 3:0 (3:0) | |
| 18:00 | Konyaspor | - | Beşiktaş | 1:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 19 | 14 | 4 | 1 | 36:14 | 22 | 46 |
| 2 |
|
Konyaspor | 19 | 11 | 6 | 2 | 32:15 | 17 | 39 |
| 3 |
|
İstanbul Başakşehir | 19 | 10 | 3 | 6 | 29:19 | 10 | 33 |
| 4 |
|
Fenerbahçe | 19 | 9 | 5 | 5 | 31:23 | 8 | 32 |
| 5 |
|
Hatayspor | 19 | 10 | 2 | 7 | 27:23 | 4 | 32 |
| 6 |
|
Adana Demirspor | 19 | 8 | 6 | 5 | 27:22 | 5 | 30 |
| 7 |
|
Beşiktaş | 19 | 8 | 4 | 7 | 30:28 | 2 | 28 |
| 8 |
|
Alanyaspor | 19 | 8 | 4 | 7 | 29:31 | -2 | 28 |
| 9 |
|
Gaziantep FK | 19 | 8 | 4 | 7 | 24:26 | -2 | 28 |
| 10 |
|
Galatasaray | 19 | 7 | 6 | 6 | 24:23 | 1 | 27 |
| 11 |
|
Fatih Karagümrük SK | 19 | 7 | 6 | 6 | 26:27 | -1 | 27 |
| 12 |
|
Sivasspor | 19 | 6 | 8 | 5 | 26:20 | 6 | 26 |
| 13 |
|
Kayserispor | 19 | 6 | 6 | 7 | 27:28 | -1 | 24 |
| 14 |
|
Giresunspor | 19 | 6 | 4 | 9 | 19:19 | 0 | 22 |
| 15 |
|
Antalyaspor | 19 | 6 | 4 | 9 | 21:27 | -6 | 22 |
| 16 |
|
Altay Izmir | 19 | 5 | 3 | 11 | 23:32 | -9 | 18 |
| 17 |
|
Çaykur Rizespor | 19 | 5 | 2 | 12 | 17:34 | -17 | 17 |
| 18 |
|
Kasımpaşa SK | 19 | 3 | 6 | 10 | 19:28 | -9 | 15 |
| 19 |
|
Göztepe | 19 | 3 | 6 | 10 | 18:28 | -10 | 15 |
| 20 |
|
Yeni Malatyaspor | 19 | 4 | 3 | 12 | 16:34 | -18 | 15 |
| Champions League | |
| CL Ronda previa | |
| ECL Ronda previa | |
| Descenso |
