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| 30.10.2021 | 13:00 | FK Mariupol | - | Dinamo Kiev | 2:3 (1:2) | |
| 16:00 | Shakhtar Donetsk | - | Desna Chernigov | 4:1 (2:1) | ||
| 18:30 | Inhulets Petrove | - | NK Veres | 0:0 (0:0) | ||
| 31.10.2021 | 13:00 | Kolos Kovalivka | - | FK Lviv | 0:1 (0:0) | |
| 16:00 | Rukh Lviv | - | FK Oleksandriya | 0:0 (0:0) | ||
| 18:30 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 (1:2) | ||
| 01.11.2021 | 16:00 | SK Dnipro-1 | - | FC Mynai | 4:0 (3:0) | |
| 18:30 | Vorskla Poltava | - | Chernomorets Odessa | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Dinamo Kiev | 13 | 11 | 2 | 0 | 34:5 | 29 | 35 |
| 2 |
|
Shakhtar Donetsk | 13 | 10 | 2 | 1 | 35:7 | 28 | 32 |
| 3 |
|
Zorya Lugansk | 13 | 8 | 2 | 3 | 30:16 | 14 | 26 |
| 4 |
|
Vorskla Poltava | 13 | 7 | 4 | 2 | 21:10 | 11 | 25 |
| 5 |
|
SK Dnipro-1 | 13 | 8 | 1 | 4 | 20:14 | 6 | 25 |
| 6 |
|
FK Oleksandriya | 13 | 5 | 5 | 3 | 12:10 | 2 | 20 |
| 7 |
|
NK Veres | 13 | 5 | 4 | 4 | 12:12 | 0 | 19 |
| 8 |
|
Metalist 1925 Kharkiv | 13 | 6 | 1 | 6 | 16:20 | -4 | 19 |
| 9 |
|
Desna Chernigov | 13 | 5 | 3 | 5 | 15:21 | -6 | 18 |
| 10 |
|
Rukh Lviv | 12 | 3 | 4 | 5 | 10:14 | -4 | 13 |
| 11 |
|
Kolos Kovalivka | 13 | 3 | 3 | 7 | 8:19 | -11 | 12 |
| 12 |
|
FK Lviv | 13 | 2 | 4 | 7 | 9:20 | -11 | 10 |
| 13 |
|
FC Mynai | 13 | 1 | 6 | 6 | 9:19 | -10 | 9 |
| 14 |
|
Inhulets Petrove | 12 | 2 | 3 | 7 | 9:22 | -13 | 9 |
| 15 |
|
Chernomorets Odessa | 13 | 1 | 5 | 7 | 12:26 | -14 | 8 |
| 16 |
|
FK Mariupol | 13 | 1 | 1 | 11 | 15:32 | -17 | 4 |
| CL Ronda previa | |
| ECL Ronda previa | |
| Permanencia | |
| Descenso |
