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| 05.11.2021 | 18:30 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 (1:0) | |
| 06.11.2021 | 13:00 | FC Mynai | - | FK Mariupol | 0:2 (0:1) | |
| 16:00 | Dinamo Kiev | - | Vorskla Poltava | 1:2 (0:1) | ||
| 18:30 | Chernomorets Odessa | - | Rukh Lviv | 4:3 (2:0) | ||
| 07.11.2021 | 13:00 | Inhulets Petrove | - | SK Dnipro-1 | 0:1 (0:1) | |
| 16:00 | Kolos Kovalivka | - | Shakhtar Donetsk | 1:3 (1:2) | ||
| 16:00 | Zorya Lugansk | - | NK Veres | 3:0 (0:0) | ||
| 18:30 | FK Lviv | - | Desna Chernigov | 0:2 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Shakhtar Donetsk | 14 | 11 | 2 | 1 | 38:8 | 30 | 35 |
| 2 |
|
Dinamo Kiev | 14 | 11 | 2 | 1 | 35:7 | 28 | 35 |
| 3 |
|
Zorya Lugansk | 14 | 9 | 2 | 3 | 33:16 | 17 | 29 |
| 4 |
|
Vorskla Poltava | 14 | 8 | 4 | 2 | 23:11 | 12 | 28 |
| 5 |
|
SK Dnipro-1 | 14 | 9 | 1 | 4 | 21:14 | 7 | 28 |
| 6 |
|
FK Oleksandriya | 14 | 6 | 5 | 3 | 14:10 | 4 | 23 |
| 7 |
|
Desna Chernigov | 14 | 6 | 3 | 5 | 17:21 | -4 | 21 |
| 8 |
|
NK Veres | 14 | 5 | 4 | 5 | 12:15 | -3 | 19 |
| 9 |
|
Metalist 1925 Kharkiv | 14 | 6 | 1 | 7 | 16:22 | -6 | 19 |
| 10 |
|
Rukh Lviv | 13 | 3 | 4 | 6 | 13:18 | -5 | 13 |
| 11 |
|
Kolos Kovalivka | 14 | 3 | 3 | 8 | 9:22 | -13 | 12 |
| 12 |
|
Chernomorets Odessa | 14 | 2 | 5 | 7 | 16:29 | -13 | 11 |
| 13 |
|
FK Lviv | 14 | 2 | 4 | 8 | 9:22 | -13 | 10 |
| 14 |
|
FC Mynai | 14 | 1 | 6 | 7 | 9:21 | -12 | 9 |
| 15 |
|
Inhulets Petrove | 13 | 2 | 3 | 8 | 9:23 | -14 | 9 |
| 16 |
|
FK Mariupol | 14 | 2 | 1 | 11 | 17:32 | -15 | 7 |
| CL Ronda previa | |
| ECL Ronda previa | |
| Permanencia | |
| Descenso |
