| 3. Jornada | 22.01.2022 | Club Tijuana [Sub 16] | - | Atlético San Luis [Sub 16] | 2:0 | ||||
| 6. Jornada | 12.02.2022 | Club León [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | Santos Laguna [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 | ||||
| 13. Jornada | 02.04.2022 | UANL Tigres [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 | ||||
| 16. Jornada | 23.04.2022 | Mazatlán FC [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 |
México