| 1. Jornada | 10.02.2022 | Patronato de Paraná | - | Argentinos Juniors | 0:1 | ||||
| 2. Jornada | 15.02.2022 | Argentinos Juniors | - | Newell's Old Boys | 3:0 | ||||
| 3. Jornada | 23.02.2022 | Racing Club | - | Argentinos Juniors | 3:0 |  |
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| 4. Jornada | 28.02.2022 | Argentinos Juniors | - | San Lorenzo | 1:1 | ||||
| 5. Jornada | 05.03.2022 | Gimnasia de La Plata | - | Argentinos Juniors | 2:2 | ||||
| 6. Jornada | 15.03.2022 | Argentinos Juniors | - | Defensa y Justicia | 0:1 | ||||
| 7. Jornada | 22.03.2022 | Argentinos Juniors | - | Vélez Sarsfield | 1:0 | ||||
| 8. Jornada | 02.04.2022 | Banfield | - | Argentinos Juniors | 0:2 | ||||
| 9. Jornada | 11.04.2022 | River Plate | - | Argentinos Juniors | 4:2 | ||||
| 10. Jornada | 17.04.2022 | Argentinos Juniors | - | Talleres de Córdoba | 2:1 | ||||
| 11. Jornada | 21.04.2022 | Atlético Tucumán | - | Argentinos Juniors | 2:4 | ||||
| 12. Jornada | 26.04.2022 | Argentinos Juniors | - | Sarmiento de Junín | 0:0 | ||||
| 13. Jornada | 03.05.2022 | Platense | - | Argentinos Juniors | 1:1 | ||||
| 14. Jornada | 08.05.2022 | Argentinos Juniors | - | Unión de Santa Fe | 2:1 |
Argentina