| 1. Jornada | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 |  |
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| 2. Jornada | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
| 9. Jornada | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 12. Jornada | 26.03.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 | ||||
| 14. Jornada | 06.04.2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 |
México