| 1. Jornada | 08.01.2022 | Pumas UNAM [Sub 16] | - | Cruz Azul [Sub 16] | 1:2 |  |
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| 2. Jornada | 15.01.2022 | CF América [Sub 16] | - | Pumas UNAM [Sub 16] | 1:0 | ||||
| 3. Jornada | 22.01.2022 | Pumas UNAM [Sub 16] | - | FC Juárez [Sub 16] | 3:0 | ||||
| 5. Jornada | 05.02.2022 | Pumas UNAM [Sub 16] | - | CF Pachuca [Sub 16] | 4:0 | ||||
| 9. Jornada | 05.03.2022 | Pumas UNAM [Sub 16] | - | Club Necaxa [Sub 16] | 1:1 | ||||
| 11. Jornada | 19.03.2022 | Pumas UNAM [Sub 16] | - | CF América [Sub 16] | 1:0 | ||||
| 14. Jornada | 30.03.2022 | Pumas UNAM [Sub 16] | - | Gallos Blancos [Sub 16] | 3:0 | ||||
| 16. Jornada | 23.04.2022 | Pumas UNAM [Sub 16] | - | Deportivo Toluca [Sub 16] | 3:4 | ||||
| 17. Jornada | 30.04.2022 | Club Necaxa [Sub 16] | - | Pumas UNAM [Sub 16] | 2:1 | ||||
| 18. Jornada | 07.05.2022 | Pumas UNAM [Sub 16] | - | Puebla FC [Sub 16] | 1:1 |
México