Entradas
| a partir de | Apellido | Pos | Equipo | Equipo | ||
|---|---|---|---|---|---|---|
| 12/2021 |  | Guzman Montgomery | AN-J | |||
| 09/2021 | | Leandro Méndez | M | |||
| 09/2021 | | Ramiro Méndez | P | |||
| 08/2021 | | Marco Mancebo | D |  | Defensor Sporting | Defensor |
| 08/2021 | | Agustín Dávila | A |  | Peñarol | Peñarol |
| 08/2021 | | Nicolás González | A |  | River Plate | River Plate |
| 08/2021 | | Guzmán Rodríguez | D | | River Plate | River Plate |
| 08/2021 | | Damián Silva | M | | Defensor Sporting | Defensor |
| 08/2021 | | Gonzalo Bueno | A | | Defensor Sporting | Defensor |
| 07/2021 | | Pablo Furtado | M | |||
| 06/2021 | | Ignacio Ithurralde | DT | |||
| 06/2021 | | Fabián Yantorno | As | |||
| 04/2021 | | Martín Fernández | M |  | CA Cerro | CA Cerro |
| 04/2021 | | Gastón Álvarez | D | | Defensor Sporting | Defensor |
| 04/2021 | | Álex de Freitas | D |  | Deportivo Maldonado | Maldonado |
| 04/2021 | | Christian Pintado | M |  | Tacuarembó | Tacuarembó |
| 04/2021 | | Alan Rodríguez | M | | Defensor Sporting | Defensor |
| 04/2021 | | Facundo Labandeira | A |  | Danubio | Danubio |
| 04/2021 | | Alexander Machado | A | | CA Cerro | CA Cerro |
| 04/2021 | | Maximiliano Pérez | A |  | Alianza FC | Alianza |
| 03/2021 | | Lucas Villalba | M |  | Boston River U20 | U20 |
| 02/2021 | | Mathías Tomás | M |  | Juventud de Las Piedras | Juventud |
| 01/2021 |  | Matías Sosa | M |  | Talleres (RdE) | Talleres |
| 01/2021 | | Juan Moreira | A |  | Villa Española | Española |
Salidas
| a partir de | Apellido | Pos | Equipo | Equipo | ||
|---|---|---|---|---|---|---|
| 08/2021 | | Sebastián Gorga | D |  | Central Español | Español |
| 08/2021 | | Wiston Fernández | M | | Danubio | Danubio |
| 08/2021 | | Luciano Olaizola | M |  | Progreso | Progreso |
| 08/2021 | | Juan Moreira | A |  | Racing | Racing |
| 08/2021 | | Rubén Bentancourt | A | | Peñarol | Peñarol |
| 07/2021 | | Mauricio Fratta | P |  | Rocha | Rocha |
| 04/2021 | | Santiago Arias | M | | Progreso | Progreso |
| 04/2021 | | Robert Flores | M | | Villa Española | Española |
| 04/2021 | | Nicolás Barán | D |  | Sud América | Sud América |
| 04/2021 | | Diego Gurri | M | | Progreso | Progreso |
| 04/2021 | | Brian Leis | A |  | Uruguay Montevideo | Uru Montevideo |
| 03/2021 | | Matías Rigoleto | A |  | San Luis | San Luis |
| 03/2021 |  | Weverton | D |  | Rio Branco - ES | Rio Branco |
| 03/2021 | | Matías Sosa | M | | Talleres (RdE) | Talleres |
| 01/2021 | | Emiliano Álvarez | D | | Defensor Sporting | Defensor |
| 01/2021 |  | Dany Cure | A |  | Deportivo La Guaira | Deportivo La Guaira |