17. Jornada
04.11.2021 16:00
05.11.2021 16:00
05.11.2021 16:30
06.11.2021 18:00
06.11.2021 18:15
06.11.2021 18:30
07.11.2021 16:00
07.11.2021 18:00
10.11.2021 19:00
| # | Team | Team | Pun. | V | E | D | Goles | DG | P. | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Santos Laguna | Santos Laguna | 17 | 10 | 4 | 3 | 38:21 | 17 | 34 |
| 2 |  | Cruz Azul | Cruz Azul | 17 | 7 | 8 | 2 | 15:9 | 6 | 29 |
| 3 |  | Deportivo Toluca | Deportivo Toluca | 17 | 9 | 2 | 6 | 24:19 | 5 | 29 |
| 4 |  | CF América | CF América | 17 | 7 | 6 | 4 | 25:19 | 6 | 27 |
| 5 |  | UANL Tigres | UANL Tigres | 17 | 8 | 2 | 7 | 24:19 | 5 | 26 |
| 6 |  | Atlas Guadalajara | Atlas Guadalajara | 17 | 7 | 5 | 5 | 23:21 | 2 | 26 |
| 7 |  | Mazatlán FC | Mazatlán FC | 17 | 7 | 4 | 6 | 31:30 | 1 | 25 |
| 8 |  | Club León | Club León | 17 | 7 | 3 | 7 | 19:19 | 0 | 24 |
| 9 |  | Atlético San Luis | Atlético San Luis | 17 | 7 | 2 | 8 | 27:27 | 0 | 23 |
| 10 |  | Deportivo Guadalajara | Deportivo Guadalajara | 17 | 7 | 2 | 8 | 22:26 | -4 | 23 |
| 11 |  | CF Pachuca | CF Pachuca | 17 | 5 | 7 | 5 | 24:19 | 5 | 22 |
| 12 |  | Puebla FC | Puebla FC | 17 | 5 | 7 | 5 | 26:31 | -5 | 22 |
| 13 |  | Pumas UNAM | Pumas UNAM | 17 | 6 | 3 | 8 | 27:26 | 1 | 21 |
| 14 |  | Club Necaxa | Club Necaxa | 17 | 5 | 6 | 6 | 25:28 | -3 | 21 |
| 15 |  | Club Tijuana | Club Tijuana | 17 | 5 | 6 | 6 | 25:29 | -4 | 21 |
| 16 |  | CF Monterrey | CF Monterrey | 17 | 5 | 4 | 8 | 25:25 | 0 | 19 |
| 17 |  | Gallos Blancos | Gallos Blancos | 17 | 4 | 6 | 7 | 19:29 | -10 | 18 |
| 18 |  | FC Juárez | FC Juárez | 17 | 1 | 5 | 11 | 11:33 | -22 | 8 |
- Playoff
| # | Team | Team | Pun. | V | E | D | Goles | DG | P. | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | Santos Laguna | Santos Laguna | 9 | 8 | 0 | 1 | 25:10 | 15 | 24 |
| 2 | | UANL Tigres | UANL Tigres | 9 | 7 | 1 | 1 | 17:6 | 11 | 22 |
| 3 | | Mazatlán FC | Mazatlán FC | 9 | 6 | 2 | 1 | 20:12 | 8 | 20 |
| 4 | | Deportivo Toluca | Deportivo Toluca | 8 | 6 | 1 | 1 | 15:5 | 10 | 19 |
| 5 | | Club León | Club León | 8 | 5 | 2 | 1 | 13:7 | 6 | 17 |
| 6 | | CF Monterrey | CF Monterrey | 8 | 4 | 3 | 1 | 16:7 | 9 | 15 |
| 7 | | CF América | CF América | 9 | 4 | 3 | 2 | 15:10 | 5 | 15 |
| 8 | | Pumas UNAM | Pumas UNAM | 9 | 5 | 0 | 4 | 19:15 | 4 | 15 |
| 9 | | Puebla FC | Puebla FC | 9 | 4 | 3 | 2 | 12:11 | 1 | 15 |
| 10 | | Cruz Azul | Cruz Azul | 8 | 3 | 5 | 0 | 10:6 | 4 | 14 |
| 11 | | Club Tijuana | Club Tijuana | 9 | 4 | 2 | 3 | 14:12 | 2 | 14 |
| 12 | | Club Necaxa | Club Necaxa | 8 | 3 | 4 | 1 | 14:8 | 6 | 13 |
| 13 | | Atlético San Luis | Atlético San Luis | 8 | 4 | 1 | 3 | 10:8 | 2 | 13 |
| 14 | | Atlas Guadalajara | Atlas Guadalajara | 9 | 3 | 4 | 2 | 13:12 | 1 | 13 |
| 15 | | CF Pachuca | CF Pachuca | 9 | 3 | 3 | 3 | 15:10 | 5 | 12 |
| 16 | | Deportivo Guadalajara | Deportivo Guadalajara | 8 | 2 | 1 | 5 | 9:13 | -4 | 7 |
| 17 | | FC Juárez | FC Juárez | 8 | 1 | 3 | 4 | 6:10 | -4 | 6 |
| 18 | | Gallos Blancos | Gallos Blancos | 8 | 1 | 3 | 4 | 9:16 | -7 | 6 |
- Playoff
| # | Team | Team | Pun. | V | E | D | Goles | DG | P. | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | | Deportivo Guadalajara | Deportivo Guadalajara | 9 | 5 | 1 | 3 | 13:13 | 0 | 16 |
| 2 | | Cruz Azul | Cruz Azul | 9 | 4 | 3 | 2 | 5:3 | 2 | 15 |
| 3 | | Atlas Guadalajara | Atlas Guadalajara | 8 | 4 | 1 | 3 | 10:9 | 1 | 13 |
| 4 | | CF América | CF América | 8 | 3 | 3 | 2 | 10:9 | 1 | 12 |
| 5 | | Gallos Blancos | Gallos Blancos | 9 | 3 | 3 | 3 | 10:13 | -3 | 12 |
| 6 | | Santos Laguna | Santos Laguna | 8 | 2 | 4 | 2 | 13:11 | 2 | 10 |
| 7 | | CF Pachuca | CF Pachuca | 8 | 2 | 4 | 2 | 9:9 | 0 | 10 |
| 8 | | Atlético San Luis | Atlético San Luis | 9 | 3 | 1 | 5 | 17:19 | -2 | 10 |
| 9 | | Deportivo Toluca | Deportivo Toluca | 9 | 3 | 1 | 5 | 9:14 | -5 | 10 |
| 10 | | Club Necaxa | Club Necaxa | 9 | 2 | 2 | 5 | 11:20 | -9 | 8 |
| 11 | | Puebla FC | Puebla FC | 8 | 1 | 4 | 3 | 14:20 | -6 | 7 |
| 12 | | Club Tijuana | Club Tijuana | 8 | 1 | 4 | 3 | 11:17 | -6 | 7 |
| 13 | | Club León | Club León | 9 | 2 | 1 | 6 | 6:12 | -6 | 7 |
| 14 | | Pumas UNAM | Pumas UNAM | 8 | 1 | 3 | 4 | 8:11 | -3 | 6 |
| 15 | | Mazatlán FC | Mazatlán FC | 8 | 1 | 2 | 5 | 11:18 | -7 | 5 |
| 16 | | UANL Tigres | UANL Tigres | 8 | 1 | 1 | 6 | 7:13 | -6 | 4 |
| 17 | | CF Monterrey | CF Monterrey | 9 | 1 | 1 | 7 | 9:18 | -9 | 4 |
| 18 | | FC Juárez | FC Juárez | 9 | 0 | 2 | 7 | 5:23 | -18 | 2 |
- Playoff