Plan de juego
| Fecha | Ronda | Partido | Partido | Res. | Espectadores | |
|---|---|---|---|---|---|---|
| 12.02.2022 |  | 2. Jornada | Plaza Colonia - River Plate | CAP - Riv | 0:1 | |
| 25.02.2022 | | 4. Jornada | Plaza Colonia - Fénix | CAP - Fén | 1:1 | |
| 20.03.2022 | | 6. Jornada | Plaza Colonia - Albion | CAP - AFC | 1:1 | |
| 25.04.2022 | | 10. Jornada | Plaza Colonia - Rentistas | CAP - C.A | 0:3 | |
| 29.05.2022 | | 14. Jornada | Plaza Colonia - Wanderers | CAP - MWF | 1:0 | |
| 14.06.2022 | | Grupo B | Plaza Colonia - Boston River | CAP - Bos | 0:0 | |
| 26.06.2022 | | Grupo B | Plaza Colonia - Cerrito | CAP - Cer | 3:0 | |
| 16.07.2022 | | Grupo B | Plaza Colonia - River Plate | CAP - Riv | 0:0 | |
| 30.07.2022 | | 1. Jornada | Plaza Colonia - Boston River | CAP - Bos | 1:1 | |
| 13.08.2022 | | 3. Jornada | Plaza Colonia - Cerro Largo | CAP - CLF | 2:0 | |
| 28.08.2022 | | 5. Jornada | Plaza Colonia - Defensor | CAP - Def | 0:1 | |
| 17.09.2022 | | 9. Jornada | Plaza Colonia - Maldonado | CAP - Dep | 0:1 | |
| 22.09.2022 |  | Octavos de final | Plaza Colonia - Cerro Largo | CAP - CLF | 1:0 | |
| 01.10.2022 | | 11. Jornada | Plaza Colonia - Liverpool FC | CAP - LFC | 1:3 | |
| 12.10.2022 | | 13. Jornada | Plaza Colonia - Torque | CAP - MCT | 0:2 | |
| 23.10.2022 | | 15. Jornada | Plaza Colonia - Cerrito | CAP - Cer | 1:3 |