Plan de juego
| Fecha | Ronda | Partido | Partido | Res. | Espectadores | |
|---|---|---|---|---|---|---|
| 20.02.2022 |  | 21. Jornada | FK Senica - ŠKF Sereď | SEN - SER | 1:2 | 412 |
| 12.03.2022 | | 2. Jornada | FK Senica - MFK Zemplín | SEN - ZEM | 2:1 | 273 |
| 09.04.2022 | | 5. Jornada | FK Senica - FK Pohronie | SEN - | 2:1 | 283 |
| 16.04.2022 | | 6. Jornada | FK Senica - MFK Tatran | SEN - TAT | 0:3 | 313 |
| 20.04.2022 |  | Semifinales | FK Senica - Spartak Trnava | SEN - TRN | 0:4 | |
| 30.04.2022 | | 8. Jornada | FK Senica - Zlaté Moravce | SEN - ZLM | 0:0 | 328 |
| 14.05.2022 | | 9. Jornada | FK Senica - AS Trenčín | SEN - AST | 0:3 | 323 |