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| 12.03.2022 | 20:00 | Real Santa Cruz | - | Always Ready | 0:1 (0:0) | |
| 20:00 | Atlético Palmaflor | - | Universitario de Vinto | 1:0 (1:0) | ||
| 13.03.2022 | 01:00 | Oriente Petrolero | - | Blooming | 1:2 (0:1) | |
| 20:00 | Nacional Potosí | - | Real Tomayapo | 5:0 (4:0) | ||
| 20:00 | Club Aurora | - | Jorge Wilstermann | 1:0 (1:0) | ||
| 22:30 | Universitario de Sucre | - | Independiente Petrolero | 1:2 (1:0) | ||
| 15.03.2022 | 00:00 | The Strongest | - | Bolívar | 0:1 (0:1) | |
| 21.03.2022 | 01:30 | CD Guabirá | - | Royal Pari | 0:3 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Palmaflor | 6 | 4 | 1 | 1 | 7:6 | 1 | 13 |
| 2 |
|
Nacional Potosí | 6 | 3 | 2 | 1 | 14:7 | 7 | 11 |
| 3 |
|
The Strongest | 6 | 3 | 2 | 1 | 9:4 | 5 | 11 |
| 4 |
|
Oriente Petrolero | 6 | 3 | 0 | 3 | 7:7 | 0 | 9 |
| 5 |
|
Universitario de Sucre | 6 | 2 | 2 | 2 | 8:8 | 0 | 8 |
| 6 |
|
Club Aurora | 6 | 1 | 3 | 2 | 5:7 | -2 | 6 |
| 7 |
|
Real Santa Cruz | 6 | 0 | 2 | 4 | 5:9 | -4 | 2 |
| 8 |
|
CD Guabirá | 6 | 0 | 2 | 4 | 4:11 | -7 | 2 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 6 | 4 | 1 | 1 | 14:2 | 12 | 13 |
| 2 |
|
Blooming | 6 | 4 | 1 | 1 | 12:11 | 1 | 13 |
| 3 |
|
Real Tomayapo | 6 | 2 | 3 | 1 | 5:8 | -3 | 9 |
| 4 |
|
Royal Pari | 6 | 2 | 2 | 2 | 8:7 | 1 | 8 |
| 5 |
|
Always Ready | 6 | 2 | 2 | 2 | 5:7 | -2 | 8 |
| 6 |
|
Independiente Petrolero | 6 | 2 | 1 | 3 | 7:8 | -1 | 7 |
| 7 |
|
Jorge Wilstermann | 6 | 2 | 1 | 3 | 3:4 | -1 | 7 |
| 8 |
|
Universitario de Vinto | 6 | 1 | 1 | 4 | 4:11 | -7 | 4 |
| Playoff | |
| Playoff |
