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| 09.04.2022 | 12:00 | Southampton FC | - | Crystal Palace | 3:2 (0:1) | |
| 12:00 | West Ham United | - | Tottenham Hotspur | 3:5 (2:1) | ||
| 12:00 | West Bromwich Albion | - | Brighton & Hove Albion | 1:5 (0:2) | ||
| 13:00 | Aston Villa | - | Reading FC | 1:2 (1:0) | ||
| 13:00 | Birmingham City | - | Arsenal FC | 1:1 (1:0) | ||
| 13:00 | Chelsea FC | - | Leicester City | 0:2 (0:0) | ||
| 13:00 | Norwich City | - | Fulham FC | 1:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Southampton FC | 23 | 17 | 2 | 4 | 69:31 | 38 | 53 |
| 2 |
|
West Ham United | 23 | 15 | 4 | 4 | 59:25 | 34 | 49 |
| 3 |
|
Crystal Palace | 23 | 14 | 4 | 5 | 54:28 | 26 | 46 |
| 4 |
|
Chelsea FC | 23 | 14 | 3 | 6 | 62:39 | 23 | 45 |
| 5 |
|
Fulham FC | 23 | 13 | 4 | 6 | 46:26 | 20 | 43 |
| 6 |
|
Leicester City | 23 | 12 | 5 | 6 | 43:28 | 15 | 41 |
| 7 |
|
Arsenal FC | 23 | 11 | 6 | 6 | 49:42 | 7 | 39 |
| 8 |
|
Brighton & Hove Albion | 23 | 9 | 3 | 11 | 54:52 | 2 | 30 |
| 9 |
|
Tottenham Hotspur | 23 | 9 | 1 | 13 | 48:57 | -9 | 28 |
| 10 |
|
Reading FC | 23 | 7 | 3 | 13 | 35:50 | -15 | 24 |
| 11 |
|
West Bromwich Albion | 23 | 7 | 2 | 14 | 34:61 | -27 | 23 |
| 12 |
|
Aston Villa | 23 | 5 | 4 | 14 | 42:64 | -22 | 19 |
| 13 |
|
Birmingham City | 23 | 3 | 4 | 16 | 28:67 | -39 | 13 |
| 14 |
|
Norwich City | 23 | 2 | 1 | 20 | 17:70 | -53 | 7 |
| Playoff |
