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| 04.12.2010 | 13:00 | FK Rabotnički | - | FK Pelister | 3:0 (1:0) | |
| 13:00 | FK Teteks | - | Sileks Kratovo | 1:1 (0:0) | ||
| 13:00 | Napredok Kičevo | - | FK Turnovo | 0:1 (0:0) | ||
| 13:00 | FK Skopje | - | Vardar Skopje | 1:0 (0:0) | ||
| 05.12.2010 | 13:00 | FK Bregalnica Štip | - | Metalurg Skopje | 1:2 (0:1) | |
| 13:00 | KF Shkëndija 79 | - | FK Renova | 4:1 (3:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 17 | 9 | 5 | 3 | 30:10 | 20 | 32 |
| 2 |
|
FK Renova | 17 | 9 | 4 | 4 | 23:12 | 11 | 31 |
| 3 |
|
FK Rabotnički | 17 | 8 | 5 | 4 | 23:15 | 8 | 29 |
| 4 |
|
Metalurg Skopje | 17 | 8 | 5 | 4 | 19:13 | 6 | 29 |
| 5 |
|
FK Turnovo | 17 | 9 | 2 | 6 | 19:15 | 4 | 29 |
| 6 |
|
FK Teteks | 17 | 6 | 6 | 5 | 16:12 | 4 | 24 |
| 7 |
|
Napredok Kičevo | 17 | 7 | 3 | 7 | 17:20 | -3 | 24 |
| 8 |
|
FK Skopje | 17 | 6 | 4 | 7 | 12:12 | 0 | 22 |
| 9 |
|
FK Bregalnica Štip | 17 | 7 | 1 | 9 | 17:23 | -6 | 22 |
| 10 |
|
Sileks Kratovo | 17 | 5 | 6 | 6 | 17:21 | -4 | 21 |
| 11 |
|
Vardar Skopje | 17 | 4 | 1 | 12 | 12:28 | -16 | 10 |
| 12 |
|
FK Pelister | 17 | 2 | 2 | 13 | 9:33 | -24 | 8 |
| CL Ronda previa | |
| Europa League | |
| Permanencia | |
| Descenso |
