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| 04.03.2022 | 19:00 | Mainz II | - | SV 07 Elversberg | 0:2 (0:2) | |
| 05.03.2022 | 14:00 | Bahlinger SC | - | Stuttgart II | 0:0 (0:0) | |
| 14:00 | FK Pirmasens | - | FSV Frankfurt | 0:1 (0:0) | ||
| 14:00 | Hessen Kassel | - | SSV Ulm 1846 | 0:0 (0:0) | ||
| 14:00 | TSG Balingen | - | SG Sonnenhof Großaspach | 3:2 (0:1) | ||
| 14:00 | TSV Schott Mainz | - | FC 08 Homburg | 0:3 (0:1) | ||
| 14:00 | VfR Aalen | - | TSV Steinbach Haiger | 0:2 (0:1) | ||
| 06.03.2022 | 14:00 | FC-Astoria Walldorf | - | Kickers Offenbach | 1:2 (0:0) | |
| 14:00 | Hoffenheim II | - | Rot-Weiß Koblenz | 1:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Mainz II | 26 | 17 | 1 | 8 | 44:30 | 14 | 52 |
| 2 |
|
SV 07 Elversberg | 25 | 15 | 6 | 4 | 54:22 | 32 | 51 |
| 3 |
|
TSV Steinbach Haiger | 26 | 14 | 8 | 4 | 47:28 | 19 | 50 |
| 4 |
|
SSV Ulm 1846 | 25 | 14 | 7 | 4 | 40:24 | 16 | 49 |
| 5 |
|
Kickers Offenbach | 25 | 15 | 3 | 7 | 43:19 | 24 | 48 |
| 6 |
|
FC 08 Homburg | 26 | 12 | 6 | 8 | 38:36 | 2 | 42 |
| 7 |
|
Bahlinger SC | 25 | 10 | 6 | 9 | 23:25 | -2 | 36 |
| 8 |
|
Hessen Kassel | 26 | 9 | 8 | 9 | 31:27 | 4 | 35 |
| 9 |
|
TSG Balingen | 25 | 10 | 4 | 11 | 36:47 | -11 | 34 |
| 10 |
|
FC-Astoria Walldorf | 26 | 8 | 7 | 11 | 38:44 | -6 | 31 |
| 11 |
|
VfR Aalen | 25 | 9 | 4 | 12 | 37:47 | -10 | 31 |
| 12 |
|
Rot-Weiß Koblenz | 25 | 7 | 9 | 9 | 27:32 | -5 | 30 |
| 13 |
|
Hoffenheim II | 26 | 7 | 8 | 11 | 38:40 | -2 | 29 |
| 14 |
|
Stuttgart II | 26 | 7 | 7 | 12 | 34:38 | -4 | 28 |
| 15 |
|
FSV Frankfurt | 26 | 6 | 9 | 11 | 29:36 | -7 | 27 |
| 16 |
|
SG Sonnenhof Großaspach | 26 | 7 | 5 | 14 | 33:52 | -19 | 26 |
| 17 |
|
FC Gießen | 25 | 6 | 7 | 12 | 22:31 | -9 | 25 |
| 18 |
|
FK Pirmasens | 26 | 6 | 6 | 14 | 22:41 | -19 | 24 |
| 19 |
|
TSV Schott Mainz | 26 | 6 | 5 | 15 | 26:43 | -17 | 23 |
| Ascenso | |
| Descenso |
