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| 05.02.2022 | 11:30 | Keçiörengücü | - | Samsunspor | 1:1 (1:0) | |
| 11:30 | Tuzlaspor | - | Balıkesirspor | 0:2 (0:2) | ||
| 14:00 | Bursaspor | - | Altınordu FK | 1:0 (1:0) | ||
| 17:00 | Denizlispor | - | Eyüpspor | 2:2 (0:2) | ||
| 06.02.2022 | 11:30 | Bandırmaspor | - | Ümraniyespor | 2:0 (1:0) | |
| 11:30 | BB Erzurumspor | - | Manisa FK | 1:0 (1:0) | ||
| 14:00 | Menemen Belediyespor | - | Adanaspor | 2:1 (0:0) | ||
| 17:00 | Gençlerbirliği | - | MKE Ankaragücü | 0:3 (0:1) | ||
| 07.02.2022 | 18:00 | Kocaelispor | - | Boluspor | 1:2 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 22 | 15 | 3 | 4 | 37:16 | 21 | 48 |
| 2 |
|
Ümraniyespor | 22 | 14 | 3 | 5 | 37:19 | 18 | 45 |
| 3 |
|
BB Erzurumspor | 22 | 12 | 5 | 5 | 35:24 | 11 | 41 |
| 4 |
|
Eyüpspor | 22 | 11 | 7 | 4 | 35:24 | 11 | 40 |
| 5 |
|
Bandırmaspor | 22 | 12 | 3 | 7 | 36:21 | 15 | 39 |
| 6 |
|
İstanbulspor AŞ | 21 | 11 | 3 | 7 | 35:25 | 10 | 36 |
| 7 |
|
Samsunspor | 21 | 9 | 7 | 5 | 32:24 | 8 | 34 |
| 8 |
|
Adanaspor | 22 | 9 | 5 | 8 | 27:23 | 4 | 32 |
| 9 |
|
Tuzlaspor | 22 | 8 | 6 | 8 | 22:22 | 0 | 30 |
| 10 |
|
Manisa FK | 22 | 8 | 4 | 10 | 25:28 | -3 | 28 |
| 11 |
|
Boluspor | 21 | 7 | 6 | 8 | 23:23 | 0 | 27 |
| 12 |
|
Keçiörengücü | 22 | 7 | 6 | 9 | 29:33 | -4 | 27 |
| 13 |
|
Menemen Belediyespor | 22 | 6 | 8 | 8 | 26:36 | -10 | 26 |
| 14 |
|
Gençlerbirliği | 22 | 8 | 2 | 12 | 24:35 | -11 | 26 |
| 15 |
|
Kocaelispor | 22 | 7 | 3 | 12 | 21:30 | -9 | 24 |
| 16 |
|
Bursaspor | 22 | 6 | 5 | 11 | 24:34 | -10 | 23 |
| 17 |
|
Altınordu FK | 22 | 7 | 1 | 14 | 27:46 | -19 | 22 |
| 18 |
|
Denizlispor | 22 | 5 | 5 | 12 | 22:34 | -12 | 20 |
| 19 |
|
Balıkesirspor | 21 | 3 | 2 | 16 | 16:36 | -20 | 11 |
| Ascenso | |
| Playoff | |
| Descenso |
