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| I | Metalist Kharkiv | - | Olympiacos | 0:1 (0:0) | ||
| V | Olympiacos | - | Metalist Kharkiv | 1:2 (1:0) | ||
| I: 08.03.2012 19:00 | V: 15.03.2012 21:05 | Campeones: Metalist Kharkiv | ||||
| I | Sporting CP | - | Manchester City | 1:0 (0:0) | ||
| V | Manchester City | - | Sporting CP | 3:2 (0:2) | ||
| I: 08.03.2012 19:00 | V: 15.03.2012 21:05 | Campeones: Sporting CP | ||||
| I | FC Twente | - | Schalke | 1:0 (0:0) | ||
| V | Schalke | - | FC Twente | 4:1 (1:1) | ||
| I: 08.03.2012 19:00 | V: 15.03.2012 21:05 | Campeones: Schalke | ||||
| I | Atlético | - | Beşiktaş | 3:1 (3:0) | ||
| V | Beşiktaş | - | Atlético | 0:3 (0:1) | ||
| I: 08.03.2012 19:00 | V: 15.03.2012 21:05 | Campeones: Atlético | ||||
| I | Standard Liège | - | Hannover | 2:2 (2:1) | ||
| V | Hannover | - | Standard Liège | 4:0 (2:0) | ||
| I: 08.03.2012 21:05 | V: 15.03.2012 19:00 | Campeones: Hannover | ||||
| I | Valencia | - | PSV | 4:2 (3:0) | ||
| V | PSV | - | Valencia | 1:1 (0:0) | ||
| I: 08.03.2012 21:05 | V: 15.03.2012 19:00 | Campeones: Valencia | ||||
| I | AZ Alkmaar | - | Udinese | 2:0 (0:0) | ||
| V | Udinese | - | AZ Alkmaar | 2:1 (2:1) | ||
| I: 08.03.2012 21:05 | V: 15.03.2012 19:00 | Campeones: AZ Alkmaar | ||||
| I | Manchester United | - | Athletic | 2:3 (1:1) | ||
| V | Athletic | - | Manchester United | 2:1 (1:0) | ||
| I: 08.03.2012 21:05 | V: 15.03.2012 19:00 | Campeones: Athletic | ||||
