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| 22.01.2022 | 18:45 | Vitesse | - | FC Groningen | 1:3 (0:1) | |
| 20:00 | AZ Alkmaar | - | SC Cambuur | 0:0 (0:0) | ||
| 20:00 | sc Heerenveen | - | PEC Zwolle | 0:1 (0:1) | ||
| 21:00 | Willem II | - | FC Twente | 0:1 (0:1) | ||
| 23.01.2022 | 12:15 | NEC Nijmegen | - | Feyenoord | 1:4 (1:1) | |
| 14:30 | Heracles Almelo | - | Go Ahead Eagles | 1:1 (1:0) | ||
| 14:30 | PSV | - | AFC Ajax | 1:2 (0:1) | ||
| 16:45 | Sparta Rotterdam | - | FC Utrecht | 0:3 (0:1) | ||
| 20:00 | RKC Waalwijk | - | Fortuna Sittard | 2:1 (2:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta | 1.ª parte | 2.ª parte |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AFC Ajax | 20 | 15 | 3 | 2 | 61:5 | 56 | 48 |
| 2 |
|
PSV | 20 | 15 | 1 | 4 | 48:26 | 22 | 46 |
| 3 |
|
Feyenoord | 20 | 13 | 3 | 4 | 46:19 | 27 | 42 |
| 4 |
|
FC Twente | 20 | 11 | 5 | 4 | 31:22 | 9 | 38 |
| 5 |
|
AZ Alkmaar | 20 | 11 | 3 | 6 | 37:24 | 13 | 36 |
| 6 |
|
Vitesse | 20 | 11 | 3 | 6 | 27:28 | -1 | 36 |
| 7 |
|
FC Utrecht | 20 | 9 | 5 | 6 | 36:26 | 10 | 32 |
| 8 |
|
SC Cambuur | 20 | 9 | 3 | 8 | 33:40 | -7 | 30 |
| 9 |
|
NEC Nijmegen | 20 | 7 | 5 | 8 | 25:30 | -5 | 26 |
| 10 |
|
sc Heerenveen | 20 | 7 | 4 | 9 | 20:28 | -8 | 25 |
| 11 |
|
FC Groningen | 20 | 5 | 7 | 8 | 23:29 | -6 | 22 |
| 12 |
|
RKC Waalwijk | 20 | 5 | 7 | 8 | 23:31 | -8 | 22 |
| 13 |
|
Go Ahead Eagles | 20 | 6 | 4 | 10 | 20:32 | -12 | 22 |
| 14 |
|
Heracles Almelo | 20 | 5 | 5 | 10 | 22:27 | -5 | 20 |
| 15 |
|
Willem II | 20 | 5 | 3 | 12 | 18:39 | -21 | 18 |
| 16 |
|
Sparta Rotterdam | 20 | 2 | 8 | 10 | 16:31 | -15 | 14 |
| 17 |
|
Fortuna Sittard | 20 | 3 | 4 | 13 | 21:50 | -29 | 13 |
| 18 |
|
PEC Zwolle | 20 | 3 | 3 | 14 | 12:32 | -20 | 12 |
| Champions League | |
| CL Ronda previa | |
| EL Ronda previa | |
| ECL Ronda previa | |
| Playoff | |
| Playoff | |
| Descenso |
