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| 13.10.2021 | 08:30 | Shenzhen FC | - | Shaanxi Warriors Beyond | 7:0 (5:0) | |
| 09:30 | Guangzhou FC | - | Qingdao Youth Island | 0:1 (0:1) | ||
| 09:30 | Tianjin Jinmen Tiger | - | Beijing BSU | 3:0 (2:0) | ||
| 10:00 | Chongqing Liangjiang Athletic | - | Wuhan Three Towns | 2:0 (0:0) | ||
| 12:00 | Changchun Yatai | - | Zhejiang Professional | 4:0 (1:0) | ||
| 13:30 | Shandong Taishan | - | Nantong Zhiyun | 1:0 (0:0) | ||
| 13:30 | Meixian Qiuxiang | - | Henan Songshan Longmen | 1:5 (1:1) | ||
| 13:30 | Dalian Pro | - | China | 2:1 (1:1) | ||
| 14.10.2021 | 08:30 | Cangzhou Mighty Lions | - | Zibo Cuju | 5:1 (1:0) | |
| 09:30 | Wuhan FC | - | Dandong Tengyue | 7:0 (3:0) | ||
| 09:30 | Hebei FC | - | Shaanxi Chang'an Athletic | 0:1 (0:1) | ||
| 10:00 | Guangzhou City | - | Chengdu Rongcheng | 4:5 (0:1, 1:1) pn. | ||
| 12:00 | Shanghai Shenhua | - | Sichuan Minzu | 3:0 (1:0) | ||
| 13:30 | Qingdao FC | - | Kunshan FC | 3:2 (2:1) | ||
| 13:30 | Beijing Guoan | - | Sichuan Jiuniu | 2:3 (1:1, 1:1) pn. | ||
| 13:30 | Shanghai Port FC | - | Xi'an Wolves FC | 1:0 (0:0) |
