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| I | Fostiras FC | - | Panionios GSS | 1:0 (1:0) | ||
| V | Panionios GSS | - | Fostiras FC | 2:1 (2:0) | ||
| I: 28.11.2012 13:30 | V: 19.12.2012 19:00 | Campeones: Fostiras FC | ||||
| I | Levadiakos | - | Pierikos Katerini | 2:0 (1:0) | ||
| V | Pierikos Katerini | - | Levadiakos | 0:5 (0:2) | ||
| I: 28.11.2012 17:30 | V: 20.12.2012 19:00 | Campeones: Levadiakos | ||||
| I | OFI Heraklion | - | Apollon Smyrnis | 1:0 (0:0) | ||
| V | Apollon Smyrnis | - | OFI Heraklion | 2:0 (1:0, 1:0) pró. | ||
| I: 28.11.2012 17:30 | V: 22.12.2012 16:00 | Campeones: Apollon Smyrnis | ||||
| I | Olympiacos | - | Panachaiki GE | 2:0 (0:0) | ||
| V | Panachaiki GE | - | Olympiacos | 0:3 | ||
| I: 28.11.2012 19:30 | V: 19.12.2012 19:00 | Campeones: Olympiacos | ||||
| I | Tyrnavos FC | - | AO Kerkyra | 0:2 (0:1) | ||
| V | AO Kerkyra | - | Tyrnavos FC | 0:0 (0:0) | ||
| I: 29.11.2012 13:30 | V: 20.12.2012 16:00 | Campeones: AO Kerkyra | ||||
| I | Panthrakikos | - | Niki Volou FC | 2:0 (1:0) | ||
| V | Niki Volou FC | - | Panthrakikos | 1:1 (0:0) | ||
| I: 29.11.2012 17:30 | V: 19.12.2012 16:00 | Campeones: Panthrakikos | ||||
| I | Panathinaikos | - | AO Proodeftiki | 4:0 (2:0) | ||
| V | AO Proodeftiki | - | Panathinaikos | 1:2 (1:0) | ||
| I: 29.11.2012 17:30 | V: 19.12.2012 13:00 | Campeones: Panathinaikos | ||||
| I | PAS Giannina | - | Panserraikos | 1:0 (1:0) | ||
| V | Panserraikos | - | PAS Giannina | 0:2 (0:1) | ||
| I: 29.11.2012 19:30 | V: 23.12.2012 19:00 | Campeones: PAS Giannina | ||||
| I | Veria FC | - | Thrasyvoulos Fylis | 0:0 (0:0) | ||
| V | Thrasyvoulos Fylis | - | Veria FC | 0:2 (0:1) | ||
| I: 12.12.2012 17:30 | V: 20.12.2012 16:00 | Campeones: Veria FC | ||||
| I | GS Kallithea | - | Aris Saloniki | 3:1 (1:0) | ||
| V | Aris Saloniki | - | GS Kallithea | 2:1 (1:0) | ||
| I: 12.12.2012 17:30 | V: 23.12.2012 19:00 | Campeones: GS Kallithea | ||||
| I | Olympiacos Volou | - | Atromitos | 1:1 (1:0) | ||
| V | Atromitos | - | Olympiacos Volou | 2:2 (1:0) | ||
| I: 12.12.2012 19:30 | V: 22.12.2012 19:00 | Campeones: Olympiacos Volou | ||||
| I | AE Lárissa | - | Asteras Tripolis | 0:0 (0:0) | ||
| V | Asteras Tripolis | - | AE Lárissa | 4:1 (2:0) | ||
| I: 12.12.2012 19:30 | V: 22.12.2012 16:00 | Campeones: Asteras Tripolis | ||||
| I | Platanias Chanion | - | Anagennisi Karditsa | 3:1 (2:1) | ||
| V | Anagennisi Karditsa | - | Platanias Chanion | 0:1 (0:1) | ||
| I: 13.12.2012 15:30 | V: 23.12.2012 16:00 | Campeones: Platanias Chanion | ||||
| I | AO Kavala | - | AEK Athen | 0:0 (0:0) | ||
| V | AEK Athen | - | AO Kavala | 0:1 (0:0) | ||
| I: 13.12.2012 17:30 | V: 20.12.2012 19:00 | Campeones: AO Kavala | ||||
| I | Ethnikos Gazoros | - | Skoda Xanthi | 1:1 (0:0) | ||
| V | Skoda Xanthi | - | Ethnikos Gazoros | 5:4 (0:1, 1:1, 1:1) pn. | ||
| I: 13.12.2012 19:30 | V: 23.12.2012 16:00 | Campeones: Skoda Xanthi | ||||
| I | Aiginiakos FC | - | PAOK Saloniki | 1:3 (1:2) | ||
| V | PAOK Saloniki | - | Aiginiakos FC | 2:1 (1:0) | ||
| I: 13.12.2012 19:30 | V: 22.12.2012 19:00 | Campeones: PAOK Saloniki | ||||
