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| 07.09.2022 | 20:00 | Red Boys Aspelt | - | Jeunesse Biwer | 1:4 | |
| 20:00 | FC Kopstal | - | Minière Lasauvage | 2:3 | ||
| 20:00 | FC Koerich/Simmern | - | US Boevange | 4:0 | ||
| 20:00 | AS Wincrange | - | US Reisdorf | 3:1 | ||
| 20:00 | Olympia Christnach | - | CS Obercorn | 0:3 | ||
| 20:00 | Claravallis Clervaux | - | Rupensia Lusitanos Larochette | 0:6 | ||
| 20:00 | FC Ehlerange | - | US Rambrouch | 4:2 |
