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| 14.09.2022 | 15:00 | FC Visoca | - | Speranța Drochia | 0:2 | |
| 15:00 | FC Edineţ | - | FC Iskra-Stal | 0:2 | ||
| 15:00 | FCM Ungheni | - | FC Floreşti | 0:3 | ||
| 15:00 | Locomotiva Ocnița | - | FC Pepeni | 1:0 | ||
| 15:00 | La Familia Bender | - | FC Sîngerei | 3:0 | ||
| 15:00 | FC Văsieni | - | Victoria Bardar | 0:5 | ||
| 15:00 | FC Maiak Chirsova | - | FC Stăuceni | 0:2 | ||
| 15:00 | Univer-Oguzsport | - | Olimp Comrat | 2:0 |
