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| 04.02.2022 | 18:45 | Atlético San Luis | - | Santos Laguna | 0:2 (0:0) | |
| 05.02.2022 | 16:00 | CF Monterrey | - | Club León | 1:0 (1:0) | |
| 16:30 | Club Necaxa | - | Puebla FC | 4:0 (0:0) | ||
| 17:00 | Mazatlán FC | - | UANL Tigres | 1:2 (1:0) | ||
| 18:30 | Deportivo Toluca | - | Cruz Azul | 1:1 (0:0) | ||
| 18:30 | Gallos Blancos | - | FC Juárez | 1:0 (1:0) | ||
| 19:00 | Club Tijuana | - | Deportivo Guadalajara | 1:2 (1:0) | ||
| 19:30 | Pumas UNAM | - | CF Pachuca | 4:3 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 5 | 5 | 0 | 0 | 12:6 | 6 | 15 |
| 2 |
|
CF Pachuca | 4 | 3 | 0 | 1 | 12:5 | 7 | 9 |
| 3 |
|
Gallos Blancos | 5 | 2 | 2 | 1 | 3:5 | -2 | 8 |
| 4 |
|
Club Necaxa | 4 | 2 | 0 | 2 | 9:4 | 5 | 6 |
| 5 |
|
CF América | 4 | 2 | 0 | 2 | 6:5 | 1 | 6 |
| 6 |
|
FC Juárez | 4 | 2 | 0 | 2 | 4:3 | 1 | 6 |
| 7 |
|
Deportivo Toluca | 5 | 1 | 2 | 2 | 4:7 | -3 | 5 |
| 8 |
|
Puebla FC | 4 | 0 | 1 | 3 | 0:7 | -7 | 1 |
| 9 |
|
Cruz Azul | 5 | 0 | 1 | 4 | 4:12 | -8 | 1 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UANL Tigres | 4 | 4 | 0 | 0 | 9:3 | 6 | 12 |
| 2 |
|
Deportivo Guadalajara | 5 | 3 | 2 | 0 | 9:2 | 7 | 11 |
| 3 |
|
Atlas Guadalajara | 4 | 3 | 0 | 1 | 9:3 | 6 | 9 |
| 4 |
|
Club Tijuana | 5 | 3 | 0 | 2 | 11:7 | 4 | 9 |
| 5 |
|
Santos Laguna | 4 | 2 | 1 | 1 | 5:3 | 2 | 7 |
| 6 |
|
CF Monterrey | 5 | 2 | 1 | 2 | 7:7 | 0 | 7 |
| 7 |
|
Atlético San Luis | 5 | 1 | 0 | 4 | 2:12 | -10 | 3 |
| 8 |
|
Mazatlán FC | 4 | 0 | 0 | 4 | 4:11 | -7 | 0 |
| 9 |
|
Club León | 4 | 0 | 0 | 4 | 3:11 | -8 | 0 |
| Playoff | |
| Playoff |
