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| I | Santos Laguna | - | CF América | 4:1 (2:1) | ||
| V | CF América | - | Santos Laguna | 2:2 (2:1) | ||
| I: 11.05.2018 02:30 | V: 14.05.2018 02:00 | Campeones: Santos Laguna | ||||
| I | Club Tijuana | - | Deportivo Toluca | 2:1 (1:0) | ||
| V | Deportivo Toluca | - | Club Tijuana | 4:1 (2:0) | ||
| I: 11.05.2018 04:30 | V: 13.05.2018 19:00 | Campeones: Deportivo Toluca | ||||
